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A Misleading Diagnosis of Sarcoidosis in an Older Woman
Abire Allaoui, Wassila Bouissar, Khadija Echchilali, Mina Moudatir, Fatim Zahra Alaoui, Hassan Elkabli
http://dx.doi.org/10.12890/2017_000463
European Journal of Case Reports in Internal Medicine - © EFIM

ABSTRACT

Common variable immunodeficiency (CVID) is the most frequent primary immunodeficiency and has a reported prevalence of approximately 1:25,000 to 1:50,000. The fact that it is rarely considered as a diagnosis in adults can lead to diagnostic delay, especially in older patients, and to complications such as bronchiectasis and excess mortality. However, practitioners should first exclude common causes of hypogammaglobulinaemia before considering CVID. Here we present a case of CVID revealed by prolonged fever and complicated with granulomatous manifestations and bronchiectasis in an older woman without a history of recurrent infections.

KEYWORDS

Common variable immunodeficiency, Granulomatosis, aged

References
  1. Gathmann B, Mahlaoui N, Gerard L,et al,. Clinical picture and treatment of 2212 patients with common variable immunodeficiency. J Allergy Clin Immunol. 2014;134:116–26.
  2. Boursiquot J-N, Gérard L, Malphettes M, et al, . Granulomatous disease in CVID: retrospective analysis of clinical characteristics and treatment efficacy in a cohort of 59 patients. J Clin Immunol 2013;33(1):84–95.
  3. Abbott JK, Gelfend EW. Common Variable Immunodeficiency: Diagnosis, Management, and Treatment. Immunol Allergy Clin North Am. 2015;35(4):637-58.
  4. Prezzo A, Cavaliere FM, Bilotta C, Iacobini M, Quinti I. Intravenous immunoglobulin replacement treatment does not alter polymorphonuclear leukocytes function and surface receptors expression in patients with common variable immunodeficiency. Cell Immunol. 2016.
  5. Pandit C, Hsu P, van Asperen P, Mehr S,. Respiratory manifestations and management in children with Common Variable Immunodeficiency. Paediatr Respir Rev. 2016.


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