Intralobar Pulmonary Sequestration and Increased Serum CA 19-9
  • Massimo Montalto
    Department of Internal Medicine, Gemelli Hospital, Catholic University, Rome
  • Michele Impagnatiello
    Department of Internal Medicine, Gemelli Hospital, Catholic University, Rome
  • Maria Anna Nicolazzi
    Department of Internal Medicine, Gemelli Hospital, Catholic University, Rome
  • Maria Teresa Congedo
  • Raffaele Landolfi
    Department of Internal Medicine, Gemelli Hospital, Catholic University, Rome

Abstract

Intralobar pulmonary sequestration is an uncommon congenital lung anomaly which consists of a mass of normal lung tissue not connected to the normal tracheobronchial tree and supplied by an anomalous systemic artery. Carbohydrate antigen 19-9 (CA 19-9) is widely accepted as a tumour marker for biliary, pancreatic and gastrointestinal cancer. However, CA 19-9 may also be increased in patients with benign disease. We describe the case of a 56-year-old woman with intralobar pulmonary sequestration who underwent unnecessary and extensive diagnostic abdominal examinations because of an increase in CA 19-9 serum levels.

VIEW THE ENTIRE ARTICLE

References

  • Savic B, Birtel FJ, Tholen W, Funke HD, Knoche R. Lung sequestration: report of seven cases and review of 540 published cases. Thorax 1979;34:96–101.
  • Ahn YH, Song MJ, Park SH. Intralobar pulmonary sequestration showing increased serum CA19-9. Tuberc Respir Dis 2012;72:507–510.
  • Armbruster C, Kriwanek S, Feichtinger H, Armbruster C. Intra-abdominal sequestration of the lung and elevated serum levels of CA 19-9: a diagnostic pitfall. HPB (Oxford) 2004;6:45–48.
  • Kristensen KL, Duus LA, Elle B. Endovascular treatment of an aneurysmal aberrant systemic artery supplying a pulmonary sequestrum. Cardiovasc Intervent Radiol 2015;38:1308–1311.
  • Gupta MK, Arciaga R, Bocci L, Tubbs R, Bukowski R, Deodhar SD. Measurement of a monoclonal-antibody- defined antigen (CA19-9) in the sera of patients with malignant and nonmalignant diseases: comparison with carcinoembryonic antigen. Cancer 1985;56:277–283.
  • Dong J, Cai Y, Chen R, Du S, Chen Y, Shi K. A case report and a short literature review of pulmonary sequestration showing elevated serum levels of carbohydrate antigen 19-9. J Nippon Med Sch 2015;82:211–215.
  • Montalto M, Santoro L, Vastola M, Curigliano V, Ricci R, Vecchio FM, et al. Normalisation of high CA 19-9 values in autoimmune hepatitis after steroidal treatment. Int J Immunopathol Pharmacol 2005;18:603–607.
  • Views: 991
    HTML downloads: 364
    PDF downloads: 366
    learning point downloads: 0


    Published: 2017-05-26
    Issue: Vol. 4 No. 4 (view)


    How to cite:
    1.
    Montalto M, Impagnatiello M, Nicolazzi MA, Congedo MT, Landolfi R. Intralobar Pulmonary Sequestration and Increased Serum CA 19-9. EJCRIM 2017;4 doi:10.12890/2017_000583.

    Similar Articles

    You may also start an advanced similarity search for this article.

    Most read articles by the same author(s)