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When Hypereosinophilia Leads to Stroke
Emilie Chalayer, Aude Pelissier, Bernard Tardy
European Journal of Case Reports in Internal Medicine - © EFIM


AFIP1L1-PDGFRA fusion can only be confirmed through molecular and cytogenetic investigations causing a delay in the diagnosis. However, patients with this mutation need urgent treatment because they present hypereosinophilia which may be associated with short-term tissue damage. Thromboembolism is a known cause of death in hypereosinophilic syndrome. A case of Loeffler endocarditis due to FIP1L1-PDGFRA-associated chronic eosinophilic leukemia presenting hemiparesis with fever, which also mislead the initial diagnosis, is reported.


Hypereosinophilia, stroke, cytomegalovirus, Loeffer endocarditis

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