Cardiac Amyloidosis Associated with Apolipoprotein A-IV Deposition Diagnosed by Mass Spectrometry-Based Proteomic Analysis
  • Elisabete Martins
    Faculty of Medicine, University of Porto, Portugal
  • Joana Urbano
    Department of Internal Medicine, Centro Hospitalar do Alto Minho, Viana do Castelo, Portugal
  • Sérgio Leite
    Department of Cardiology, Hospital Nossa Senhora Oliveira, Guimarães, Portugal
  • Adriana Pinto
    Department of Nuclear Medicine, Centro Hospitalar Universitário de São João, Porto, Portugal
  • Raquel Garcia
    Department of Cardiology, Centro Hospitalar Universitário São João, Porto, Portugal
  • Rui Bergantim
    Department of Hematology, Centro Hospitalar Universitário de São João, Porto, Portugal
  • Pedro Rodrigues Pereira
    Department of Pathology, Centro Hospitalar Universitário de São João, Porto, Portugal
  • Paulo Pinho Costa
    Department of Human Genetics, National Health Institute Doutor Ricardo Jorge, Porto, Portugal
  • Hugo Osório
    Faculty of Medicine, University of Porto, Portugal
  • Isabel Tavares
    Department of Nephrology, Centro Hospitalar Universitário São João, Porto, Portugal

Keywords

Amyloidosis, cardiomyopathy, heart failure, imaging, nuclear medicine, apolipoprotein

Abstract

Amyloidosis is a group of disorders characterised by the accumulation of extracellular deposits of insoluble protein aggregates. Clinical management depends on the accurate identification of the amyloid precursor and underlying cause. We describe a rare case of apolipoprotein A-IV cardiac amyloidosis, the diagnosis of which required mass spectrometry-based proteomic analysis.

VIEW THE ENTIRE ARTICLE

References

  • Benson MD, Buxbaum JN, Eisenberg DS, Merlini G, Saraiva MJM, Sekijima Y, et al. Amyloid nomenclature 2018: recommendations by the International Society of Amyloidosis (ISA) nomenclature committee. Amyloid 2018;25:215–219.

  • Gillmore JD, Maurer MS, Falk RH, Merlini G, Damy T, Dispenzieri A, et al. Nonbiopsy diagnosis of cardiac transthyretin amyloidosis. Circulation 2016;133:2404–2412.

  • Dasari S, Amin MS, Kurtin PJ, Vrana JA, Theis JD, Grogg KL, et al. Clinical, biopsy, and mass spectrometry characteristics of renal apolipoprotein A-IV amyloidosis. Kidney Int 2016;90:658–664.

  • Wang F, Kohan AB, Lo CM, Liu M, Howles P, Tso P. Apolipoprotein A-IV: a protein intimately involved in metabolism. J Lipid Res 2015;56:1403–1418.

  • Sun Z, Larson IA, Ordovas JM, Barnard JR, Schaefer EJ. Effects of age, gender, and lifestyle factors on plasma apolipoprotein A-IV concentrations. Atherosclerosis 2000;151:381–388.

  • Bois MC, Dasari S, Mills JR, Theis J, Highsmith WE, Vrana JA, et al. Apolipoprotein A-IV-associated cardiac amyloidosis. J Am Coll Cardiol 2017;69:2248–2249.

  • Longhi S, Bonfiglioli R, Obici L, Gagliardi C, Milandri A, Lorenzini M, et al. Etiology of amyloidosis determines myocardial 99mTc-DPD uptake in amyloidotic cardiomyopathy. Clin Nucl Med 2015;40:446–447.

  • Quarta CC, Obici L, Guidalotti PL, Pieroni M, Longhi S, Perlini S, et al. High 99mTc-DPD myocardial uptake in a patient with apolipoprotein AI-related amyloidotic cardiomyopathy. Amyloid 2013;20:48–51.

  • Picken MM. Amyloidosis-where are we now and where are we heading? Arch Pathol Lab Med 2010;134:545–551.

  • Vrana JA, Theis JD, Dasari S, Mereuta OM, Dispenzieri A, Zeldenrust SR, et al. Clinical diagnosis and typing of systemic amyloidosis in subcutaneous fat aspirates by mass spectrometry-based proteomics. Haematologica 2014;99:1239–1247.

    • Views: 1237
    HTML downloads: 297
    PDF downloads: 529

    Published: 2019-11-27
    Issue: Vol 6 No 12 (view)

    How to cite:
    1.
    Martins E, Urbano J, Leite S, Pinto A, Garcia R, Bergantim R, Pereira PR, Costa PP, Osório H, Tavares I. Cardiac Amyloidosis Associated with Apolipoprotein A-IV Deposition Diagnosed by Mass Spectrometry-Based Proteomic Analysis. EJCRIM 2019;6 doi:10.12890/2019_001237.

    Most read articles by the same author(s)