Cardiac Amyloidosis Associated with Apolipoprotein A-IV Deposition Diagnosed by Mass Spectrometry-Based Proteomic Analysis

  • Elisabete Martins Faculty of Medicine, University of Porto, Portugal
  • Joana Urbano Department of Internal Medicine, Centro Hospitalar do Alto Minho, Viana do Castelo, Portugal
  • Sérgio Leite Department of Cardiology, Hospital Nossa Senhora Oliveira, Guimarães, Portugal
  • Adriana Pinto Department of Nuclear Medicine, Centro Hospitalar Universitário de São João, Porto, Portugal
  • Raquel Garcia Department of Cardiology, Centro Hospitalar Universitário São João, Porto, Portugal
  • Rui Bergantim Department of Hematology, Centro Hospitalar Universitário de São João, Porto, Portugal
  • Pedro Rodrigues Pereira Department of Pathology, Centro Hospitalar Universitário de São João, Porto, Portugal
  • Paulo Pinho Costa Department of Human Genetics, National Health Institute Doutor Ricardo Jorge, Porto, Portugal
  • Hugo Osório Faculty of Medicine, University of Porto, Portugal
  • Isabel Tavares Department of Nephrology, Centro Hospitalar Universitário São João, Porto, Portugal
DOI: https://doi.org/10.12890/2019_001237

Keywords

Amyloidosis, cardiomyopathy, heart failure, imaging, nuclear medicine, apolipoprotein

Abstract

Amyloidosis is a group of disorders characterised by the accumulation of extracellular deposits of insoluble protein aggregates. Clinical management depends on the accurate identification of the amyloid precursor and underlying cause. We describe a rare case of apolipoprotein A-IV cardiac amyloidosis, the diagnosis of which required mass spectrometry-based proteomic analysis.

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    • Published: 2019-11-27

    Issue: LATEST ONLINE (view)

    Section: Articles

    How to cite:
    Martins, E., Urbano, J., Leite, S., Pinto, A., Garcia, R., Bergantim, R., Pereira, P., Costa, P., Osório, H., & Tavares, I. (2019). Cardiac Amyloidosis Associated with Apolipoprotein A-IV Deposition Diagnosed by Mass Spectrometry-Based Proteomic Analysis. European Journal of Case Reports in Internal Medicine, 2. https://doi.org/https://doi.org/10.12890/2019_001237