Cardiac Amyloidosis Associated with Apolipoprotein A-IV Deposition Diagnosed by Mass Spectrometry-Based Proteomic Analysis

Authors

• Elisabete Martins Faculty of Medicine, University of Porto, Portugal
• Joana Urbano Department of Internal Medicine, Centro Hospitalar do Alto Minho, Viana do Castelo, Portugal
• Sérgio Leite Department of Cardiology, Hospital Nossa Senhora Oliveira, Guimarães, Portugal
• Adriana Pinto Department of Nuclear Medicine, Centro Hospitalar Universitário de São João, Porto, Portugal
• Raquel Garcia Department of Cardiology, Centro Hospitalar Universitário São João, Porto, Portugal
• Rui Bergantim Department of Hematology, Centro Hospitalar Universitário de São João, Porto, Portugal
• Pedro Rodrigues Pereira Department of Pathology, Centro Hospitalar Universitário de São João, Porto, Portugal
• Paulo Pinho Costa Department of Human Genetics, National Health Institute Doutor Ricardo Jorge, Porto, Portugal
• Hugo Osório Faculty of Medicine, University of Porto, Portugal
• Isabel Tavares Department of Nephrology, Centro Hospitalar Universitário São João, Porto, Portugal

elisabetemartins09@gmail.com

Keywords

Abstract

Amyloidosis is a group of disorders characterised by the accumulation of extracellular deposits of insoluble protein aggregates. Clinical management depends on the accurate identification of the amyloid precursor and underlying cause. We describe a rare case of apolipoprotein A-IV cardiac amyloidosis, the diagnosis of which required mass spectrometry-based proteomic analysis.