Palmoplantar Pustulosis-like Eruption Induced by Baricitinib for Treatment of Rheumatoid Arthritis

  • Dimitra Koumaki Dermatology Department, University Hospital of Heraklion, Crete, Greece
  • Vasiliki Koumaki Microbiology Department, Medical School of Athens, Athens , Greece
  • George Bertsias Rheumatology Department, University Hospital of Heraklion, Crete, Greece
  • Eleni Lagoudaki Pathology Department, University Hospital of Heraklion, Crete, Greece
  • George Bertsias Rheumatology Department, University Hospital of Heraklion, Crete, Greece

Keywords

Palmoplantar pustulosis, baricitinib, rheumatoid arthritis, cutaneous side effects

Abstract

Objectives: Baricitinib is an orally active Janus kinase (JAK) inhibitor used in the treatment of moderate to severe rheumatoid arthritis (RA).
Materials and methods: Here, we report the case of a 56-year-old Caucasian male diagnosed with RA who developed palmoplantar pustulosis (PPP) while being treated with baricitinib.
Results: The patient’s PPP resolved after discontinuation of baricitinib and recurred when this was restarted. Based on causality assessment, it was considered a drug-induced PPP. Conclusion: To the authors’ knowledge, this is the first case of baricitinib-induced PPP.

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References

  • Damsky W, King BA. JAK inhibitors in dermatology: the promise of a new drug class. J Am Acad Dermatol 2017;76(4):736–744.

  • Koga T, Sato T, Umeda M, Fukui S, Horai Y, Kawashiri SY, et al. Successful treatment of palmoplantar pustulosis with rheumatoid arthritis, with tofacitinib: impact of this JAK inhibitor on T-cell differentiation. Clin Immunol 2016;173:147–148.


  • Haynes D, Topham C, Hagstrom E, Greiling T. Tofacitinib for the treatment of recalcitrant palmoplantar pustulosis: a case report. Australas J Dermatol Epub 2019 Jul 18. doi: 10.1111/ajd.13117.


  • Shibata T, Muto J, Hirano Y, Takama H, Yanagishita T, Ohshima Y, et al. Palmoplantar pustulosis-like eruption following tofacitinib therapy for juvenile idiopathic arthritis. JAAD Case Rep 2019;5:518–521.


  • Gündüz Ö. JAK/STAT pathway modulation: does it work in dermatology? Dermatol Ther 2019;32:e12903.
  • Published: 2019-12-19

    Issue: Vol 7 No 1 (view)

    Section: Articles

    How to cite:
    Koumaki, D., Koumaki, V., Bertsias, G., Lagoudaki, E., & Bertsias, G. (2019). Palmoplantar Pustulosis-like Eruption Induced by Baricitinib for Treatment of Rheumatoid Arthritis. European Journal of Case Reports in Internal Medicine, 7(1). https://doi.org/https://doi.org/10.12890/2019_001383

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