Kikuchi-Fujimoto Syndrome: A Rare Entity to Consider
  • Diogo Raposo André
    Internal Medicine Department, Hospital Central do Funchal, Madeira Island, Portugal
  • Filipa Vicente
    Internal Medicine Department, Hospital Central do Funchal, Madeira Island, Portugal
  • Jessica Chaves
    Internal Medicine Department, Hospital Central do Funchal, Madeira Island, Portugal
  • Mónica Caldeira
    Internal Medicine Department, Hospital Central do Funchal, Madeira Island, Portugal
  • Fernando Jacinto
    Internal Medicine Department, Hospital Central do Funchal, Madeira Island, Portugal
  • António José Chaves
    Internal Medicine Department, Hospital Central do Funchal, Madeira Island, Portugal
  • Maria Luz Brazão
    Internal Medicine Department, Hospital Central do Funchal, Madeira Island, Portugal

Keywords

Kikuchi-Fujimoto disease, lymphadenitis, fever of unknown origin, rare disease

Abstract

Introduction: Kikuchi-Fujimoto disease (KFD) is a rare, benign, necrotizing lymphadenitis of unknown aetiology with good prognosis. It is characterized by cervical lymphadenopathy, nocturnal diaphoresis and fever. Surgical excision of the adenopathy, histopathological study and immunophenotyping are crucial for diagnosis.
Patients and methods: This paper describes five patients with three different histological subtypes of KFD, including an atypical presentation masquerading as pyelonephritis and two other cases where physicians mistakenly started chemotherapy. In one other case cytomegalovirus was identified as the responsible aetiological agent, while in the remaining patient, KFD evolved into an autoimmune condition.
Discussion: KFD, although rare, may mimic infectious, autoimmune and neoplastic diseases. It also poses a risk for the subsequent development of an autoimmune disorder.

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References

  • Pandey V. Kikuchi-Fujimoto disease masquerading as acute appendicitis. J Clin Diagn Res 2017;11(6):ED26–ED28.

  • Vijayaraghavan R, Chandrashekar R, A S, Belagavi C. Kikuchi-Fujimoto’s disease involving mesenteric nodes: a report and review of literature. BMJ Case Rep 2011;2011. pii: bcr1020114945.

  • Richards MJ. Kikuchi disease. UpToDate [Internet]. Available from: https://www.uptodate.com/contents/kikuchi-disease.

  • Song JY, Lee J, Park DW, Sohn JW, Suh SI, Kim IS, et al. Clinical outcome and predictive factors of recurrence among patients with Kikuchi’s disease. Int J Infect Dis 2009;13(3):322–326.

  • Parappil A, Rifaath AA, Doi SAR, Pathan E, Surrun SK. Pyrexia of unknown origin: Kikuchi-Fujimoto disease. Clin Infect Dis 2004;39(1):138–143.
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    Published: 2020-04-27
    Issue: 2020: Vol 7 No 7 (view)


    How to cite:
    1.
    André DR, Vicente F, Chaves J, Caldeira M, Jacinto F, Chaves AJ, Brazão ML. Kikuchi-Fujimoto Syndrome: A Rare Entity to Consider. EJCRIM 2020;7 doi:10.12890/2020_001456.

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