Immune-Mediated Necrotizing Myopathy: An Often Misdiagnosed Entity
  • Joana Almeida Espírito Santo
    Internal Medicine Department A, University Hospital Center of Coimbra, Coimbra
  • Rui Garcia
    Internal Medicine Department A, University Hospital Center of Coimbra, Coimbra
  • Benilde Barbosa
    Internal Medicine Department A, University Hospital Center of Coimbra, Coimbra
  • Olinda Rebelo
    Neuropathology Laboratory of the Neurology Department, University Hospital Center of Coimbra, Coimbra
  • José Pereira de Moura
    Internal Medicine Department A, University Hospital Center of Coimbra, Coimbra

Keywords

Myopathy, Necrotizing myopathy, Immune-mediated necrotizing myopathy

Abstract

Immune-mediated necrotizing myopathies (IMNM) are recognized as a subgroup of idiopathic inflammatory myopathies (IIM). IMNM are defined based on a combination of clinical presentation and laboratory studies, requiring a specific myopathological pattern on muscle biopsy for diagnosis. The authors describe a case of a patient with necrotizing myopathy, thought to be immune mediated, highlighting the challenge of its differential diagnosis. As clinical assessment and diagnostic tools sometimes fail to determine whether a necrotizing myopathy is immune mediated, leading to misdiagnosis and a compromise of the optimal therapeutic approach, distinguishing between IMNM and other myopathies is crucial.

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    Published: 2015-01-16
    Issue: Vol. 2 No. 1 (2015) (view)


    How to cite:
    1.
    Espírito Santo JA, Garcia R, Barbosa B, Rebelo O, Pereira de Moura J. Immune-Mediated Necrotizing Myopathy: An Often Misdiagnosed Entity. EJCRIM 2015;2 doi:10.12890/2015_000164.

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