Isolated Non-Resolving Vulvar Lesion as a Presentation of Disseminated Histoplasmosis in a Woman with HIV
  • Moni Roy
    Department of Internal Medicine, University of Illinois College of Medicine, OSF Saint Francis Medical Center, Peoria, Illinois, USA
  • Ashish Kumar Roy
    Department of Internal Medicine, University of Illinois College of Medicine, OSF Saint Francis Medical Center, Peoria, Illinois, USA
  • Jan Nalinee Upalakalin
    Department of Pathology, OSF Saint Francis Medical Center, Peoria, Illinois, USA
  • Sharjeel Ahmad
    Department of Internal Medicine, Section of Infectious Diseases, University of Illinois College of Medicine, Peoria, Illinois, USA

Keywords

Disseminated histoplasmosis, vulvar lesion, HIV, AIDS

Abstract

Disseminated histoplasmosis is most commonly caused by Histoplasma capsulatum and is a known opportunistic infection in immunocompromised patients. The clinical presentation of histoplasmosis varies from asymptomatic to a progressive disseminated form. Pulmonary and CNS involvement is common in disseminated histoplasmosis. Rarely, disseminated disease can present as vulvar lesion in the absence of pulmonary symptoms, causing a delay in diagnosis. As per our PubMed literature search, there have only been two reported cases where vulvar lesion was the only presenting symptom of disseminated disease. In our patient, a histopathological diagnosis was made with staining showing budding yeast forms of histoplasma.

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References

  • Smith MB, Schnadig VJ, Zaharopoulos P, Van Hook C. Disseminated Histoplasma capsulatum infection presenting as genital ulcerations. Obstet Gynecol 1997;89(5 Pt 2):842–844.

  • Shine MM, Shah MM, Hanna CA, Bevis KS. Vulvar histoplasmosis as a rare cause of genital ulceration. Obstet Gynecol 2013;122(2 Pt 2):449–452.

  • Friskel E, Klotz SA, Bartholomew W, Dixon A. Two unusual presentations of urogenital histoplasmosis and a review of the literature. Clin Infect Dis 2000;31(1):189–191.

  • Randhawa HS, Chaturvedi S, Khan ZU, Chaturvedi VP, Jain SK, Jain RC, et al. Epididymal histoplasmosis diagnosed by isolation of Histoplasma capsulatum from semen. Mycopathologia 1995;131(3):173–177.

  • Kauffman CA, Slama TG, Wheat LJ. Histoplasma capsulatum epididymitis. J Urol 1981;125(3):434–435.

  • Sachdev R, Goel RK, Malviya S, Goel S, Gajendra S. Scrotal histoplasmosis masquerading as Fournier's gangrene. Int J Surg Pathol 2017;25(6):509–510.
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    Published: 2020-07-16
    Issue: 2020: Vol 7 No 10 (view)


    How to cite:
    1.
    Roy M, Roy AK, Upalakalin JN, Ahmad S. Isolated Non-Resolving Vulvar Lesion as a Presentation of Disseminated Histoplasmosis in a Woman with HIV. EJCRIM 2020;7 doi:10.12890/2020_001814.

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