Cutaneous Angiosarcoma in an Unusual Location and Without Predisposing Factors
KeywordsCutaneous angiosarcoma, lower limbs, predisposing factors, immunohistochemistry
Cutaneous angiosarcoma is a rare, highly malignant tumour of vascular endothelial origin. It usually arises in the skin and superficial soft tissue, mostly on the head and neck. It presents as a variety of lesions, and so is considered a great mimicker, leading to a delay in diagnosis and evidencing the importance of biopsy with immunohistochemistry confirmation. There are few reports of extremity involvement in patients with pre-existing chronic lymphoedema, or exposure to radiation therapy. We report the case of an 82-year-old woman with lower limb extensive cutaneous involvement, distant metastatic disease, and poor therapy response. Its rare location without predisposing factors highlights the need to raise awareness about this disease
Nakano K, Takahashi S. Precision medicine in soft tissue sarcoma treatment. Cancers 2020;12:221.
Cao J, Wang J, He C, Fang M. Angiosarcoma: a review of diagnosis and current treatment. Am J Cancer Res 2019;9(11):2303–2313.
Requena C, Alsina M, Morgado-Carrasco D, Cruz J, Sanmartín O, Serra-Guillén C, et al. Sarcoma de Kaposi y angiosarcoma cutáneo: directrices para el diagnóstico y tratamiento. Actas Dermo-Sifiliográficas 2018;109(10):878–887.
Lewcun JA, Pameijer C, Kass R, Cream L, Hershock D, Brooks AJ, et al. Doxorubicin, paclitaxel, and cisplatin based chemotherapy for the treatment of angiosarcoma: two case reports. Int J Surg Case Rep 2020;68:83–87.
Fujisawa Y, Yoshino K, Fujimura T, Nakamura Y, Okiyama N, Ishitsuka Y, et al. Cutaneous angiosarcoma: the possibility of new treatment options especially for patients with large primary tumor. Front Oncol 2018;8:46.
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