Hyperinsulinaemic hypoglycaemia - a diagnostic challenge. A report of two atypical cases.

  • Renata Baronaite Hansen Department of Medical Endocrinology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
  • Ulla Feldt Rasmussen Department of Medical Endocrinology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
  • Åse Krogh Rasmussen Department of Medical Endocrinology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
  • Carsten Palnaes Hansen Department of Gastrointestinal Surgery & Transplantation, Neuroendocrine Tumour Center of Excellence, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
  • Ulrich Knigge Department of Gastrointestinal Surgery & Transplantation, Neuroendocrine Tumour Center of Excellence, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

Keywords

Hyperinsulinaemic hypoglycaemia, insulinoma, glucagonoma, malignant insulinoma, nesidioblastosis.

Abstract

Objectives: The authors describe 2 atypical cases of patients with hypoglycaemia, suspected for insulinoma.

Methods: The 2 reports are accompanied by a concise review of the literature.

Results: Patient 1 had a distal pancreatectomy performed for suspected insulinoma, and was diagnosed with a glucagonoma and beta-cell hyperplasia (nesidioblastosis). To the authors’s knowledge, co-existing glucagonoma and nesidioblastosis had not been previously reported.
Patient 2 was diagnosed with a benign insulinoma and 5 years later with metastatic disease.

Conclusion: The authors conclude that insulinomas are rare entities which often present a diagnostic and therapeutic challenge. In such cases, patient referral to tertiary multidisciplinary centers is recommended.

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References

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  • Published: 2015-07-17

    Issue: Vol. 2 No. 4 (2015) (view)

    Section: Articles

    How to cite:
    1.
    Baronaite Hansen R, Feldt Rasmussen U, Krogh Rasmussen Åse, Palnaes Hansen C, Knigge U. Hyperinsulinaemic hypoglycaemia - a diagnostic challenge. A report of two atypical cases. EJCRIM 2015;2 doi:10.12890/2015_000245.