Disseminated Blastomycosis Presenting with Spontaneous Coronary Artery Dissection
  • Rahul Sehgal
    Department of Rheumatology, Mayo Clinic Alix School of Medicine, Mayo Clinic Health System, Eau Claire, Wisconsin, USA
  • D Fearghas O'Cochlain
    Department of Cardiovascular Medicine, Mayo Clinic Alix School of Medicine, Mayo Clinic Health System, Eau Claire, Wisconsin, USA
  • Andrew Virata
    Department of Pathology, Mayo Clinic Alix School of Medicine, Mayo Clinic Health System, Eau Claire, Wisconsin, USA
  • Gurpreet Singh
    Department of Cardiovascular Medicine, Mayo Clinic Alix School of Medicine, Mayo Clinic Health System, Eau Claire, Wisconsin, USA

Keywords

Spontaneous coronary artery dissection, ST-elevation myocardial infarction, blastomycosis

Abstract

Spontaneous coronary artery dissection (SCAD) is increasingly recognized as an important cause of acute coronary syndrome (ACS) and myocardial infarction (MI) in individuals with few or no known atherosclerotic risk factors. While systemic autoimmune inflammatory disorders are associated with precipitating SCAD, the role of infection-induced systemic inflammation in SCAD is not well defined. We present the case of a 49-year-old Caucasian woman with ST-elevation myocardial infarction (STEMI) diagnosed as SCAD from a severe systemic inflammatory response related to disseminated blastomycosis. Punch biopsy of a skin lesion and synovial fluid culture confirmed Blastomyces dermatitidis. This case suggests the possibility of systemic infection-induced inflammation as a precipitating factor in SCAD pathogenesis similar to autoimmune inflammatory disorders.

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    Published: 2021-04-23
    Issue: 2021: Vol 8 No 4 (view)

    How to cite:
    1.
    Sehgal R, O’Cochlain DF, Virata A, Singh G. Disseminated Blastomycosis Presenting with Spontaneous Coronary Artery Dissection. EJCRIM 2021;8 doi:10.12890/2021_002511.

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