Perianal Plasmablastic Lymphoma Masquerading as a Buschke-Löwenstein-like Tumour in an HIV-infected Patient with Recurrent Anal Condyloma

  • Xavier Rivera Rivera University of Texas Health Sciences Center at Houston, McGovern Medical School
  • Joshua Baalwa Department of Pathology and Laboratory Medicine, The University of Texas Health Sciences Center at Houston, McGovern Medical School, Houston, Texas, USA

Keywords

Buschke-Löwenstein like tumor, antiretroviral therapy associated immune reconstitution

Abstract

Plasmablastic lymphoma (PBL) commonly presents as a primary (de novo) oral or extraoral mucocutaneous or nodal mass lesion in patients with HIV/AIDS. PBL developing as a secondary malignancy at the same location as a pre-existing tumour is extremely rare and has never been reported in association with longstanding or recurrent anal condyloma. A Buschke-Löwenstein tumour is a rare gigantic, locally destructive condyloma that is usually located in the anogenital region. We report a case of a diagnostically and therapeutically challenging PBL that presented as a rapidly enlarging mass underlying a giant condyloma, thereby mimicking a benign Buschke-Löwenstein tumour. Clinical suspicion was further masked by the co-presence of fistulae in ano and adjacent abscess pockets at the time of diagnosis. By the time of final diagnosis, the lymphoma had disseminated to regional lymph nodes, a month later to pleural cavities and 4 months later to the leptomeninges and bilateral kidneys, leading to permanent deferral of chemotherapeutic intervention.

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  • Published: 2021-06-11

    Issue: 2021: Vol 8 No 6 (view)

    Section: Articles

    How to cite:
    1.
    Rivera Rivera X, Baalwa J. Perianal Plasmablastic Lymphoma Masquerading as a Buschke-Löwenstein-like Tumour in an HIV-infected Patient with Recurrent Anal Condyloma. EJCRIM 2021;8 doi:10.12890/2021_002552.