Renal Vein Thrombosis and Pulmonary Embolism Secondary to Vaccine-induced Thrombotic Thrombocytopenia (VITT)
  • Nikita Cliff-Patel
    East Surrey Hospital, Redhill, Surrey, United Kingdom
  • Lindsay Moncrieff
    East Surrey Hospital, Redhill, Surrey, United Kingdom
  • Veqas Ziauddin
    East Surrey Hospital, Redhill, Surrey, United Kingdom

Keywords

Vaccine-induced thrombotic thrombocytopenia, renal vein thrombosis, pulmonary embolism

Abstract

The Medicines and Healthcare products Regulatory Agency (MHRA) of the UK has approved the use of three vaccines to combat COVID-19 (SARS-CoV-2). There have been rare reports of thrombosis after vaccination with the AstraZeneca vaccine. We present three cases of vaccine-induced thrombotic thrombocytopenia (VITT) in one UK district general hospital following administration of this vaccine. Two of the patients had asymptomatic pulmonary emboli, while the other is the first known case of both renal vein thrombosis and pulmonary embolism.

VIEW THE ENTIRE ARTICLE

References

  • Vagnoni C. Covid-19 vaccines safety and blood clots. 19 May 2021. Available from: https://post.parliament.uk/covid-19-vaccines-safety-and-blood-clots/ (accessed 25 May 2021).
  • Greinacher A, Thiele T, Warkentin TE, Weisser K, Kyrle PA, Eichinger S. Thrombotic thrombocytopenia after ChAdOx1 nCoV-19 vaccination. N Engl J Med 2021;384(22):2092–2101.
  • British Society for Haematology. Guidance produced from the Expert Haematology Panel (EHP) focused on Covid-19 vaccine induced thrombosis and thrombocytopenia (VITT). 7 April 2021. Available from: https://b-s-h.org.uk/media/19530/guidance-version-13-on-mngmt-of-thrombosis-with-thrombocytopenia-occurring-after-c-19-vaccine_20210407.pdf (accessed 25 May 2021).
  • Hursting MJ, Lewis BE, Macfarlane DE. Transitioning from argatroban to warfarin therapy in patients with heparin-induced thrombocytopenia. Clin Appl Thromb Hemost 2005;11:279–287.
  • Malas MB, Naazie IN, Elsayed N, Mathlouthi A, Marmor R, Clary B. Thromboembolism risk of COVID-19 is high and associated with a higher risk of mortality: a systematic review and meta-analysis. EClinicalMedicine 2020;29:100639.
  • Views: 1125
    HTML downloads: 225
    PDF downloads: 572


    Published: 2021-06-30
    Issue: 2021: Vol 8 No 6 (view)


    How to cite:
    1.
    Cliff-Patel N, Moncrieff L, Ziauddin V. Renal Vein Thrombosis and Pulmonary Embolism Secondary to Vaccine-induced Thrombotic Thrombocytopenia (VITT). EJCRIM 2021;8 doi:10.12890/2021_002692.