A Rare Case of Guillain-Barré Syndrome following COVID-19 Vaccination
  • Yash Kripalani
    Department of Critical Care Medicine, Holy Family Hospital, Bandra, Mumbai, India https://orcid.org/0000-0003-3014-2184
  • Vidyadhara Lakkappan
    Department of Critical Care Medicine, Holy Family Hospital, Bandra, Mumbai, India
  • Lipeeka Parulekar
    Department of General Internal Medicine, Holy Family Hospital, Bandra, Mumbai, India
  • Anjum Shaikh
    Department of Critical Care Medicine, Holy Family Hospital, Bandra, Mumbai, India
  • Rakesh Singh
    Department of Neurology, Holy Family Hospital, Bandra, Mumbai, India
  • Pradeep Vyas
    Department of Critical Care Medicine, Holy Family Hospital, Bandra, Mumbai, India

Keywords

Covishield, Guillain-Barré syndrome, GBS, AstraZeneca, Coronavirus, pandemic, vaccine, ChAdOx1

Abstract

Various vaccines against COVID-19 have been developed since SARS-CoV-2 emerged at the end of 2019. Their emergency administration in healthcare settings has been accompanied by numerous adverse effects. A case of Guillain-Barré syndrome following vaccination with Covishield is presented here to highlight this possible adverse condition.

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References

  • Vellozzi C, Iqbal S, Broder K. Guillain-Barré syndrome, influenza, and influenza vaccination: the epidemiologic evidence. Clin Infect Dis 2014;58(8):1149–1155. doi: 10.1093/cid/ciu005. PMID: 24415636.
  • Voysey M, Clemens SAC, Madhi SA, Weckx LY, Folegatti PM, Aley PK, et al. Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK [published correction appears in Lancet 2021;397(10269):98]. Lancet 2021;397(10269):99–111. doi: 10.1016/S0140-6736(20)32661-1
  • Barrett JR, Belij-Rammerstorfer S, Dold C, Ewer KJ, Folegatti PM, Gilbride C, et al. Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses [published correction appears in Nat Med 2021;27(6):1113]. Nat Med 2021;27(2):279–288. doi: 10.1038/s41591-020-01179-4
  • Nasuelli NA, De Marchi F, Cecchin M, De Paoli I, Onorato S, Pettinaroli R, et al. A case of acute demyelinating polyradiculoneuropathy with bilateral facial palsy after ChAdOx1 nCoV-19 vaccine. Neurol Sci 2021 Jul 17:1–3. doi: 10.1007/s10072-021-05467-w. Online ahead of print. PMID: 34272622; PMCID: PMC8285283.
  • Maramattom BV, Krishnan P, Paul R, Padmanabhan S, Cherukudal Vishnu Nampoothiri S, Syed AA, et al. Guillain-Barré syndrome following ChAdOx1-S/nCoV-19 vaccine. Ann Neurol 2021;90(2):312–314. doi: 10.1002/ana.26143. PMID: 34114256.
  • McKean N, Chircop C. Guillain-Barré syndrome after COVID-19 vaccination. BMJ Case Rep 2021;14(7):e244125. doi: 10.1136/bcr-2021-244125. PMID: 34330729.
  • Hasan T, Khan M, Khan F, Hamza G. Case of Guillain-Barré syndrome following COVID-19 vaccine. BMJ Case Rep 2021;14:e243629.
  • Razok A, Shams A, Almeer A, Zahid M. Post-COVID-19 vaccine Guillain-Barré syndrome; first reported case from Qatar. Ann Med Surg (Lond) 2021;67:102540. doi: 10.1016/j.amsu.2021.102540. PMID: 34249353; PMCID: PMC8253659.
  • Waheed S, Bayas A, Hindi F, Rizvi Z, Espinosa PS. Neurological complications of COVID-19: Guillain-Barre syndrome following Pfizer COVID-19 vaccine. Cureus 2021;13(2):e13426. doi: 10.7759/cureus.13426. PMID: 33758714; PMCID: PMC7978140.
  • Trimboli M, Zoleo P, Arabia G, Gambardella A. Guillain-Barré syndrome following BNT162b2 COVID-19 vaccine. Neurol Sci 2021 Aug 4:1–2. doi: 10.1007/s10072-021-05523-5. Online ahead of print. PMID: 34346014; PMCID: PMC8331323.
  • Finsterer J. Exacerbating Guillain-Barré syndrome eight days after vector-based COVID-19 vaccination. Case Rep Infect Dis 2021;2021:3619131. doi: 10.1155/2021/3619131. PMID: 34055430; PMCID: PMC8123983.
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    Published: 2021-10-08
    Issue: 2021: Vol 8 No 9 (view)


    How to cite:
    1.
    Kripalani Y, Lakkappan V, Parulekar L, Shaikh A, Singh R, Vyas P. A Rare Case of Guillain-Barré Syndrome following COVID-19 Vaccination. EJCRIM 2021;8 doi:10.12890/2021_002797.