Primary Central Nervous System Lymphoma with Exclusive Leptomeningeal Involvement: The Diagnostic Challenge of a Rare Presentation of an Uncommon Disease
  • Miguel Santos
    Department of Internal Medicine, Centro Hospitalar de Leiria, Leiria, Portugal
  • Tatiana Pires
    Department of Internal Medicine, Centro Hospitalar de Leiria, Leiria, Portugal
  • Ana Rodrigues
    Department of Internal Medicine, Centro Hospitalar de Leiria, Leiria, Portugal
  • Adriana Bandeira
    Department of Internal Medicine, Centro Hospitalar de Leiria, Leiria, Portugal
  • Ana Albuquerque
    Department of Internal Medicine, Centro Hospitalar de Leiria, Leiria, Portugal
  • Flávia Santos
    Department of Internal Medicine, Centro Hospitalar de Leiria, Leiria, Portugal
  • Miriam Magalhães
    Department of Internal Medicine, Centro Hospitalar de Leiria, Leiria, Portugal
  • Maria Jesus Banza
    Department of Internal Medicine, Centro Hospitalar de Leiria, Leiria, Portugal

Keywords

Primary central nervous system lymphoma, leptomeningeal lymphoma

Abstract

Primary central nervous system lymphoma (PCNSL) is a rare and aggressive extra-nodal non-Hodgkin lymphoma (NHL). It must be confined to the brain, eyes, spinal cord or leptomeninges without systemic involvement at the time of diagnosis. Disease confined to the cerebrospinal fluid (CSF) is a rare form of presentation and poses a particular diagnostic challenge.
We present the case of an 82-year-old man admitted to hospital because of an acute confusional state, later revealed to be due to PCNSL with exclusive leptomeningeal involvement. The diagnostic process was further impaired (or, perhaps, aided?) by the onset of a COVID-19 outbreak on the ward.

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References

  • Ostrom QT, Gittleman H, de Blank PM, Finlay JL,Gurney JG,McKean-Cowdin R,et al. American Brain Tumor Association adolescent and young adult primary brain and central nervous system tumors diagnosed in the United States in 2008–2012. Neuro Oncol 2016;18(Suppl 1):i1–i50.
  • Flinn IW, Ambinder RF. AIDS primary central nervous system lymphoma. Curr Opin Oncol1996;8:373.
  • Nabavizadeh SA, Vossough A, Hajmomenian M, Assadsangabi R, Mohan S. Neuroimaging in central nervous system lymphoma. Hematol Oncol Clin North Am 2016;30:799–821.
  • Han CH, Batchelor TT. Diagnosis and management of primary central nervous system lymphoma. Cancer 2017;15:4314–4324.
  • Fischer L, Martus P, Weller M,KlasenHA,RohdenB,RöthA, et al. Meningeal dissemination in primary CNS lymphoma: prospective evaluation of 282 patients. Neurology 2008;71:1102–1108.
  • Abrey LE, Ben-Porat L, Panageas KS,YahalomJ,BerkeyB,CurranW, et al. Primary central nervous system lymphoma: the Memorial Sloan-Kettering Cancer Center prognostic model. J Clin Oncol 2006;24:5711–5715.

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    Published: 2022-01-27
    Issue: 2022: Vol 9 No 1 (view)

    How to cite:
    1.
    Santos M, Pires T, Rodrigues A, Bandeira A, Albuquerque A, Santos F, Magalhães M, Banza MJ. Primary Central Nervous System Lymphoma with Exclusive Leptomeningeal Involvement: The Diagnostic Challenge of a Rare Presentation of an Uncommon Disease. EJCRIM 2022;9 doi:10.12890/2022_003107.

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