A Severe Case of Molluscum Contagiosum Immune Reconstitution Inflammatory Syndrome in a Patient with Human Immunodeficiency Virus
  • Nida Siddiqui
    Dept. of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
  • Brett Stephen Mansfield
    Dept. of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa https://orcid.org/0000-0002-8042-7041
  • Nine-Paula Olmesdahl
    Division of Anatomical Pathology, Dept. of Pathology, National Health Laboratory Service and University of the Witwatersrand, Johannesburg, South Africa https://orcid.org/0000-0003-3304-7852
  • Peter Swart
    Division of Anatomical Pathology, Dept. of Pathology, National Health Laboratory Service and University of the Witwatersrand, Johannesburg, South Africa https://orcid.org/0000-0001-5862-0331
  • Jeremy Nel
    Division of Infectious Diseases, Dept. of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa https://orcid.org/0000-0003-4115-894X

Keywords

Immune reconstitution inflammatory syndrome, molluscum contagiosum, human immunodeficiency virus, MC-IRIS

Abstract

Paradoxical immune reconstitution inflammatory syndrome (IRIS) in human immunodeficiency virus (HIV)-positive patients initiating antiretroviral treatment (ART) is caused by restored immunity to specific antigens, resulting in worsening of a pre-existing infection. Molluscum contagiosum (MC) is commonly noted in HIV-positive individuals but ART alone is usually sufficient to bring about resolution. We present a rare case of severe MC-IRIS that worsened despite immune reconstitution.

VIEW THE ENTIRE ARTICLE

References

  • Robinson G, Townsend S, Jahnke MN. Molluscum contagiosum: review and update on clinical presentation, diagnosis, risk, prevention, and treatment. Curr Derm Rep 2020;9:83–92.
  • Yang H-S, Li C-W, Hsieh F-N, Liu C-H, Lee JY-Y, Yang C-C. Molluscum contagiosum-associated immune reconstitution inflammatory syndrome in human immunodeficiency virus infection. Dermatologica Sinica 2016;34(4):196–9.
  • Osei-Sekyere B, Karstaedt AS. Immune reconstitution inflammatory syndrome involving the skin. Clin Exp Dermatol 2010;35(5):477–81.
  • Chen X, Anstey AV, Bugert JJ. Molluscum contagiosum virus infection. Lancet Infect Dis 2013;13(10):877–88.
  • Wilson EM, Sereti I. Immune restoration after antiretroviral therapy: the pitfalls of hasty or incomplete repairs. Immunol Rev 2013;254(1):343–54.

    • Views: 519
    HTML downloads: 131
    PDF downloads: 249

    Published: 2022-01-11
    Issue: 2022: Vol 9 No 1 (view)

    How to cite:
    1.
    Siddiqui N, Mansfield BS, Olmesdahl N-P, Swart P, Nel J. A Severe Case of Molluscum Contagiosum Immune Reconstitution Inflammatory Syndrome in a Patient with Human Immunodeficiency Virus. EJCRIM 2022;9 doi:10.12890/2022_003115.

    Most read articles by the same author(s)