Esophageal Bullous Pemphigoid
  • Catarina Castelo Branco
    Department of Internal Medicine, Centro Hospitalar Universitário do Porto, Porto, Portugal
  • Tomás Fonseca
    Department of Internal Medicine, Centro Hospitalar Universitário do Porto, Porto, Portugal
  • Ricardo Marcos-Pinto
    Department of Gastroenterology, Centro Hospitalar Universitário do Porto, Porto, Portugal


Bullous pemphigoid, esophagus, dementia


Bullous pemphigoid is a rare autoimmune dermatologic disease that usually occurs in the elderly. Mucous membrane lesions occur in about 10–35% of patients and are almost always limited to the oral mucous membrane. Esophageal involvement is very rare (4% of cases) and usually presents with chest pain, dysphagia, and odynophagia, though patients are frequently asymptomatic. We report the case of newly diagnosed bullous pemphigoid in a 76-year-old man with a past medical history of dementia. He presented with cutaneous manifestations but also severe gastrointestinal bleeding due to extensive esophageal involvement. Although bullous pemphigoid is mainly a skin disease, mucous membrane lesions should not be overlooked as they are associated with an even poorer outcome. A high index of suspicion for esophageal involvement is needed as its presentation can be fatal, as with our patient.



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    Published: 2022-02-01
    Issue: 2022: Vol 9 No 2 (view)

    How to cite:
    Castelo Branco C, Fonseca T, Marcos-Pinto R. Esophageal Bullous Pemphigoid. EJCRIM 2022;9 doi:10.12890/2022_003160.

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