Phentermine-Associated Atrial Fibrillation: Case Report and Literature Review
  • Nouraldeen Manasrah
    DMC Sinai Grace Hospital, Detroit, MI, USA
  • Chandima J Herath
    DMC Sinai Grace Hospital, Detroit, MI, USA
  • Ali Al Sbihi
    DMC Sinai Grace Hospital, Detroit, MI, USA
  • Sarah Alqasem
    DMC Sinai Grace Hospital, Detroit, MI, USA
  • Andrew S Kao
    DMC Sinai Grace Hospital, Detroit, MI, USA
  • Ahmed J Chaudhary
    DMC Sinai Grace Hospital, Detroit, MI, USA
  • Rana Ismail
    DMC Sinai Grace Hospital, Detroit, MI, USA

Keywords

Phentermine, obesity, Atrial fibrillation

Abstract

Obesity has become a major public health problem with increased prevalence. It is associated with cardiovascular mortality. Phentermine is approved for short-term obesity treatment in conjunction with lifestyle modifications. Palpitation is a well-documented side effect of phentermine. However atrial fibrillation (AF) is rarely reported. We present a case of new-onset AF in a healthy woman who was recently started on phentermine for weight loss.

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References

  • Jordan J, Astrup A, Engeli S, Narkiewicz K, Day WW, Finer N. Cardiovascular effects of phentermine and topiramate: a new drug combination for the treatment of obesity. J Hypertens 2014 Jun;32(6):1178–1188. doi: 10.1097/HJH.0000000000000145. PMID: 24621808; PMCID: PMC4011567.
  • National Center for Biotechnology Information. PubChem Compound Summary for CID 4771, Phentermine. Available from https://pubchem.ncbi.nlm.nih.gov/compound/Phentermine (accessed 4 February 2022).
  • Haslam D. Weight management in obesity - past and present. Int J Clin Pract 2016 Mar;70(3):206–217. doi: 10.1111/ijcp.12771. PMID: 26811245; PMCID: PMC4832440.
  • Apovian CM, Gokce N. Obesity and cardiovascular disease. Circulation 2012 Mar 6;125(9):1178-82. doi: 10.1161/CIRCULATIONAHA.111.022541. PMID: 22392865; PMCID: PMC3693443.
  • Phentermine. React Wkly 2012;1402:37. Available from https://doi.org/10.2165/00128415-201214020-00137.
  • Keppel SS, Varriale P. An unlikely cause of atrial fibrillation-induced cardiomyopathy: phentermine, a diet pill. Int J Clin Cardiol 2015;2:029.

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    Published: 2022-03-28
    Issue: 2022: Vol 9 No 3 (view)

    How to cite:
    1.
    Manasrah N, Herath CJ, Al Sbihi A, Alqasem S, Kao AS, Chaudhary AJ, Ismail R. Phentermine-Associated Atrial Fibrillation: Case Report and Literature Review. EJCRIM 2022;9 doi:10.12890/2022_003267.