Pantoprazole-related Symptomatic Hyponatremia
  • Filipa Ferreira
    Oncology Department, Hospital São Francisco Xavier - Centro Hospitalar Lisboa Ocidental
  • Sofia Mateus
    Internal Medicine Department, Hospital São Francisco Xavier - Centro Hospitalar Lisboa Ocidental
  • Ana Rita Santos
    Internal Medicine Department, Hospital São Francisco Xavier - Centro Hospitalar Lisboa Ocidental
  • Hugo Moreira
    Internal Medicine Department, Hospital São Francisco Xavier - Centro Hospitalar Lisboa Ocidental
  • Nuno Ribeiro Ferreira
    Internal Medicine Department, Hospital São Francisco Xavier - Centro Hospitalar Lisboa Ocidental

Keywords

Hyponatremia, Pantoprazole, Proton pump inhibitors, Syndrome of Inappropriate Antidiuretic Hormone Secretion

Abstract

Hyponatremia is the most common electrolyte balance disorder, especially in the elderly and polymedicated population. The authors report the case of an 83-year-old man with symptomatic severe hyponatremia due to Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) related to pantoprazole. Pantoprazole was discontinued and serum sodium levels reached normal values in two months. To the authors’ knowledge, this is the second reported case of pantoprazole-related hyponatremia and, while most patients with hyponatremia related to proton pump inhibitors have mild symptoms, this patient had severe manifestations.

VIEW THE ENTIRE ARTICLE

References

  • Spasovski G, Vanholder R, Allolio B, Annane D, Ball S, Bichet D et al. Clinical practice guideline on diagnosis and treatment of hyponatraemia. Eur J Endocrinol 2014;170:G1–G47.
  • Buon M, Gaillard C, Martin J, Fedrizzi S, Mosquet B, Coquerel A et al. Risk of proton pump inhibitor-induced mild hyponatremia in older adults. J Am Geriatr Soc 2013;61:2052–2054.
  • Durst R, Pipek R, Levy Y. Hyponatremia caused by omeprazole treatment. Am J Med 1994;97400–401.
  • Shiba S, Sugiura K, Ebata A, Kagaya T, Tomori G, Marumo F et al. Hyponatremia with consciousness disturbance caused by omeprazole administration. Digest Dis Sci 1996;41:1615–1617.
  • Naharcý M, Cintosun U, Ozturk A, Bozoglu E, Doruk H. Pantoprazole Sodium-Induced Hyponatremia in a Frail Elderly Adult. J Am Geriatr Soc 2014;62:787–788.
  • Views: 3591
    HTML downloads: 4719
    PDF downloads: 779
    Graphic 1: Evolution of sodium concentration; arrow: Pantoprazole suspension downloads: 0
    Table 1: Patient blood analysis. downloads: 0


    Published: 2016-02-18
    Issue: Vol. 3 No. 2 (view)


    How to cite:
    1.
    Ferreira F, Mateus S, Santos AR, Moreira H, Ferreira NR. Pantoprazole-related Symptomatic Hyponatremia. EJCRIM 2016;3 doi:10.12890/2015_000341.

    Most read articles by the same author(s)