First case of meningoencephalitis and bacteraemia with Flavobacterium lindanitolerans
  • Rebecca Zurbuchen
    Department of Medicine, Thun Hospital, Thun, Switzerland
  • Mirjam de Roche
    Department of Medicine, Thun Hospital, Thun, Switzerland
  • Aikaterini Galimanis
    Department of Medicine, Thun Hospital, Thun, Switzerland
  • Kerstin Narr
    Viollier AG, Allschwil, Switzerland
  • Olivier Dubuis
    Viollier AG, Allschwil, Switzerland
  • Christiane Resch
    Department of Medicine, Thun Hospital, Thun, Switzerland
  • Mairi Ziaka
    Department of Medicine, Thun Hospital, Thun, Switzerland

Keywords

Flavobacterium lindanitolerans, meningoencephalitis, gram-negative bacteria, cerebral infection, bacterial meningitis, gram-negative meningitis

Abstract

Purpose: Flavobacterium lindanitolerans is an environmental Gram-negative, non-spore-forming rod which is usually not considered to be a human pathogen. Isolation from human clinical samples has been described only once. We report the first case of meningoencephalitis and bacteraemia with Flavobacterium lindanitolerans.
Case description: A 76-year-old female presented with fever, headache, alteration of mental status, marked meningism and dysarthria. A lumbar puncture demonstrated cerebrospinal fluid findings consistent with bacterial meningitis, and a broad-spectrum antibiotic therapy was initiated. Blood and cerebrospinal fluid cultures revealed a growth of Flavobacterium lindanitolerans. Based on antimicrobial susceptibilities testing, antibiotic treatment was changed to levofloxacin, resulting in a remission of the clinical symptoms after 21 days of treatment.
Conclusion: Flavobacterium species are extremely rare human pathogens. However, some of them have been reported to cause opportunistic infections. We describe the first case of meningoencephalitis and bacteraemia caused by Flavobacterium lindanitolerans which was effectively treated with levofloxacin for 21 days.

VIEW THE ENTIRE ARTICLE

References

  • Tunkel AR, Hasbun R, Bhimraj A, Byers K, Kaplan SL, Scheld WM, et al. Infectious Diseases Society of America's Clinical Practice Guidelines for Healthcare-Associated Ventriculitis and Meningitis. Clin Infect Dis 2017;64:e34–e65.
  • Bernardet JF, Bowman JP. The genus Flavobacterium. In: Dworkin M, Falkow S, Rosenberg E, Schleifer KH, Stackebrandt E, editors. The prokaryotes: a handbook on the biology of bacteria. 3rd ed. New York: Springer, 2006:455–480.
  • Loch, TP, Faisal M. Emerging flavobacterial infections in fish: a review. J Adv Res 2015;6:283–300.
  • Vela AI, Fernandez A, Sánchez-Porro C, Sierra E, Mendez M, Arbelo M, et al. Flavobacterium ceti sp. nov., isolated from beaked whales (Ziphius cavirostris). Int J Syst Evol Microbiol 2007;57:2604–2608.
  • Sung JY, Kim TS, Shin S, Roh EY, Yoon JH, Kim E-C. Flavobacterium ceti from blood samples of a Korean patient with alcoholic liver cirrhosis. Ann Lab Med 2015;35:384–386.
  • Tian GZ, Piao DR, Zhao HY, Jiang H, Cui BY, Li JY. A Flavobacterium lindanitolerans strain isolated from the ascites sample of a Chinese patient with EV71 virus infection. Biomed Environ Sci 2011;24:694–696.
  • Park S-K, Ryoo N. A case of Flavobacterium ceti meningitis. Ann Lab Med 2016;36:614–616.
  • Mosayebi Z, Movahedian AH, Soori T. Flavobacterium sepsis outbreak due to contaminated distilled water in a neonatal intensive care unit. J Hosp Infect 2011;78:214–215.
  • Hasbun R. Healthcare-associated ventriculitis: current and emerging diagnostic and treatment strategies. Expert Rev Anti Infect Ther 2021;19:993–999.
  • Jit S, Dadhwal M, Prakash O, Lal R. Flavobacterium lindanitolerans sp. nov., isolated from hexachlorocyclohexane-contaminated soil. Int J Syst Evol Microbiol 2008;58:1665–1669.
  • LaFrentz BR, Králová S, Burbick CR, Alexander TL, Phillips CW, Griffin MJ, et al. The fish pathogen Flavobacterium columnare represents four distinct species: Flavobacterium columnare, Flavobacterium covae sp. nov., Flavobacterium davisii sp. nov. and Flavobacterium oreochromis sp. nov., and emended description of Flavobacterium columnare. Syst Appl Microbiol 2022;45:126293.
  • Maranchick NF, Alshaer MH, Smith AGC, Avaliani T, Gujabidze M, Bakuradze T, et al. Cerebrospinal fluid concentrations of fluoroquinolones and carbapenems in tuberculosis meningitis. Front Pharmacol 2022;13:1048653.
  • Views: 439
    HTML downloads: 94
    PDF downloads: 304


    Published: 2023-07-13
    Issue: 2023: Vol 10 No 8 (view)


    How to cite:
    1.
    Zurbuchen R, de Roche M, Galimanis A, Narr K, Dubuis O, Resch C, Ziaka M. First case of meningoencephalitis and bacteraemia with Flavobacterium lindanitolerans. EJCRIM 2023;10 doi:10.12890/2023_003980.