Vascular threads and nephron nests: exploring the association between Takayasu arteritis and membranous nephropathy
  • Sameen Aamer
    Department of Internal Medicine, Allegheny General Hospital, Pittsburgh, USA
  • Anand Rajan
    Department of Radiology, Allegheny General Hospital, Pittsburgh, USA
  • Swati Arora
    Division of Nephrology, Allegheny General Hospital, Pittsburgh, USA


Nephrotic syndrome, proteinuria, vasculitis, Takayasu arteritis, renal biopsy


Takayasu arteritis (TA) primarily causes ischaemic nephrosclerosis but can occasionally be associated with glomerulopathy. We report a case of a female in her twenties with PLA2-negative, THSD7A-positive membranous nephropathy (MN) refractory to rituximab, who presented with neck pain and new-onset hypertension. Blood work showed elevated inflammatory markers. Imaging of the head and neck revealed focal dilation and irregularity of the vertebral arteries, consistent with TA. The patient was started on treatment with steroids, followed by mycophenolate mofetil, which led to the resolution of symptoms and nephrotic syndrome. This case highlights an uncommon sequence of events, with MN presenting before TA, underscoring the need to consider TA in differentials for patients with MN. Notably, this is the first reported case in a young female, emphasising the need for further understanding of TA-associated glomerular diseases. Additionally, the presence of THSD7A in MN, despite negative malignancy workup, is also noteworthy.



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    Published: 2024-07-02
    Issue: 2024: LATEST ONLINE (view)

    How to cite:
    Aamer S, Rajan A, Arora S. Vascular threads and nephron nests: exploring the association between Takayasu arteritis and membranous nephropathy. EJCRIM 2024;11 doi:10.12890/2024_004557.