Refractory depressive disorder as the first manifestation of adolescent Sjögren’s syndrome, successfully treated with rituximab
  • Amal El-Ouakhoumi
    Department of Internal Medicine, University Hospital Center Mohammed VI, Marrakech, Morocco
  • Hajar Joulal
    Department of Internal Medicine, University Hospital Center Mohammed VI, Marrakech, Morocco
  • Jaouad Yousfi
    Department of Internal Medicine, University Hospital Center Mohammed VI, Marrakech, Morocco
  • Laila Benjilali
    Department of Internal Medicine, University Hospital Center Mohammed VI, Marrakech, Morocco
  • Mouna Zahlane
    Department of Internal Medicine, University Hospital Center Mohammed VI, Marrakech, Morocco
  • Lamiaa Essaadouni
    Department of Internal Medicine, University Hospital Center Mohammed VI, Marrakech, Morocco

Keywords

Primary Sjögren’s syndrome, depression, rituximab

Abstract

Background: The psychiatric manifestations of Sjögren’s syndrome are often overlooked despite their prevalence. They can be revelatory of the disease and include anxiety, depression, dementia and, rarely, psychosis.
Case description: We report a case of 18-year-old female in whom a major depressive syndrome revealed primary Sjögren’s disease, with a favourable outcome after treatment with rituximab.
Conclusion: The diagnostic of Sjögren’s syndrome should be considered in patients who present with unexplained and refractory neuropsychiatric symptoms, even in the absence of sicca symptoms.

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    Published: 2024-06-11
    Issue: 2024: Vol 11 No 7 (view)


    How to cite:
    1.
    El-Ouakhoumi A, Joulal H, Yousfi J, Benjilali L, Zahlane M, Essaadouni L. Refractory depressive disorder as the first manifestation of adolescent Sjögren’s syndrome, successfully treated with rituximab. EJCRIM 2024;11 doi:10.12890/2024_004621.