Unveiling the deadly dance of hypocalcemia and lactic acidosis in a 59-year-old woman with B-cell lymphoma
  • Yasaman Navari
    Department of Internal Medicine, Michigan State University at Hurley Medical Center, Flint, USA
  • Efosa Bazuaye
    Department of Endocrinology, University of Missouri, Columbia, USA
  • Philip J. McDonald
    Department of Internal Medicine, Division of Infectious Disease, Michigan State University at Hurley Medical Center, Flint, USA


Cardiac arrest, B-cell lymphoma, hypocalcemia


Calcium plays a crucial role in the heart’s electrical conduction system and facilitating the contraction of cardiac muscles. Hypocalcemia can result in electrocardiogram findings such as a prolonged QTC interval and eventually torsade de pointes, which in severe cases can progress to cardiac arrest. In cases of B-cell lymphoma, hypocalcemia may arise from various factors. Tumor infiltration can disrupt calcium homeostasis by affecting the parathyroid glands or bone tissue. Acidosis in the context of B-cell lymphoma can cause significant cardiovascular adverse effects. It will reduce peripheral vascular resistance and cardiac muscle contractility, promote dysrhythmias, and disturb oxygen uptake in the lungs. These combined effects markedly compromise cardiac function, increasing the likelihood of cardiac arrest. These mechanisms necessitate comprehensive management strategies in B-cell lymphoma patients. In this case report we present a case of cardiac arrest in a 59-year-old female woman with hypocalcemia and lactic acidosis secondary to B-cell lymphoma.



  • Wang X, Landaw J, Qu Z. Intracellular ion accumulation in the genesis of complex action potential dynamics under cardiac diseases. Phys Rev E 2024;109:024410.
  • Allam S, Kotloff E, Bhat A, Wang L. Severe hypocalcaemia mimicking acute coronary syndrome. BMJ Case Rep 2023;28:255652.
  • Mosebach CM, Kluger J. Probable Hypocalcemia Induced Ventricular Fibrillation and Torsades de Pointes following Blood Product Administration. Cureus 2018;21:3765.
  • Fong J, Khan A. Hypocalcemia: updates in diagnosis and management for primary care. Can Fam Physician 2012;58:158-62.
  • Cooper MS, Gittoes NJ. Diagnosis and management of hypocalcaemia. BMJ 2008;7:1298-1302.
  • Seyfrydova M, Rokyta R, Rajdl D, Huml M. Arrhythmias and laboratory abnormalities after an electrical accident: a single-center, retrospective study of 333 cases. Clin Res Cardiol 2023;112:1835-1847.
  • Wilson FP, Berns JS. Tumor lysis syndrome: new challenges and recent advances. Adv Chronic Kidney Dis 2014;21:18-26.
  • Calvo Villas JM. Tumour lysis syndrome. Med Clin 2019;17:397-404.
  • Vachvanichsanong P, Maipang M, Dissaneewate P, Wongchanchailert M, Laosombat V. Severe hyperphosphatemia following acute tumor lysis syndrome. Med Pediatr Oncol 1995;24:63-66.
  • Usui G, Hashimoto H, Uchibori Y, Usuki K, Horiuchi H, Morikawa T. Myocardial calcification in a patient with B-lymphoblastic leukemia accompanied by tumor lysis syndrome. Cardiovasc Pathol 2019;43:107146.
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    Published: 2024-06-27
    Issue: 2024: Vol 11 No 7 (view)

    How to cite:
    Navari Y, Bazuaye E, McDonald PJ. Unveiling the deadly dance of hypocalcemia and lactic acidosis in a 59-year-old woman with B-cell lymphoma. EJCRIM 2024;11 doi:10.12890/2024_004643.