Goodpasture’s Syndrome with Negative Anti-glomerular Basement Membrane Antibodies

  • Tjitske Berends-De Vries Department of Intensive Care Medicine, Ziekenhuisgroep Twente, Almelo
  • Susan Boerma Department of Internal Medicine, Isala Klinieken, Zwolle
  • Joan Doornabal Department of Internal Medicine, Isala Klinieken, Zwolle
  • Bert Dikkeschei Department of Clinical Chemistry, Isala Klinieken, Zwolle
  • Coen Stegeman Department of Nephrology, University Hospital Groningen, Groningen
  • Thiemo Veneman Department of Intensive Care Medicine, Ziekenhuisgroep Twente, Almelo
Keywords: Goodpasture, diffuse alveolar hemorrhage, anti-GBM antibodies

Abstract

A young male patient with rapidly progressive and life-threatening pulmonary haemorrhage due to anti-glomerular basement membrane (anti-GBM) antibody disease without renal involvement repeatedly tested negative for serum anti-GBM antibodies. Although rare, anti-GBM antibody disease should be considered in the differential diagnosis in patients with life-threatening pulmonary haemorrhage due to isolated diffuse alveolar haemorrhage. Enzyme-linked-immunosorbent assay (ELISA) testing for anti-GBM antibodies in anti-GBM antibody disease can give false-negative results. A negative serum anti-GBM antibody test is therefore insufficient to exclude the diagnosis. Thus, a kidney or lung biopsy should be considered in any case with a high clinical suspicion but negative anti-GBM antibody test to confirm or rule out the diagnosis.

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  • Published: 2017-10-30

    Issue: Vol 4 No 8 (view)

    Section: Articles

    How to cite:
    Berends-De Vries, T., Boerma, S., Doornabal, J., Dikkeschei, B., Stegeman, C., & Veneman, T. (2017, October 30). Goodpasture’s Syndrome with Negative Anti-glomerular Basement Membrane Antibodies. European Journal of Case Reports in Internal Medicine, 4(8). https://doi.org/https://doi.org/10.12890/2017_000687