Neurosyphilis Presenting with Papillitis

  • Martin Edward Perry Department of Rheumatology, Royal Alexandra Hospital, Paisley
  • Sarah Cooper Undergraduate Medical School, University of Glasgow, Glasgow
  • Shona Corry Undergraduate Medical School, University of Glasgow, Glasgow


neurosyphilis, papillitis, treponema pallidus


Syphilis is one of the oldest described infectious diseases in the world and is caused by the spirochete bacterium Treponema pallidum[1]. Although now a rare disease, incidence is increasing with the number of diagnoses of the disease rising in England from 1688 to 2713 between 2003 and 2012 (a 61% increase)[2]. Major outbreaks of syphilis have been documented in London, Manchester, Dublin, and Brighton particularly among men who have sex with men (MSM)[3]. Diagnosis remains difficult on account of multi-system symptoms, duration of the condition, and social stigma.



  • Centres for Disease Control and Prevention. 2015 Sexually Transmitted Diseases Treatment Guidelines – Syphilis. Available from: [accessed 30/05/2017].

  • Public Health England. Infectious Syphilis and Congenital Syphilis: Recent Epidemiology. Available from: [accessed 30/05/2017].

  • West of Scotland Sexual Health Managed Clinical Network. West of Scotland Syphilis Protocol. Available from: [accessed 30/05/2017].

  • Mehrabian S, Raycheva M, Traykova M, Stankova M, Penev L et al. Neurosyphilis with dementia and bilateral hippocampal atrophy on brain magnetic resonance imaging. BMC Neurol 2012:96 Available from: [accessed 30/05/2017].

  • Kingston M et al. UK National Guidelines on the Management of Syphilis 2015. Int J STD AIDS 2015;0:1-26 (NICE accredited). DOI: 10.1177/0956462415624059.
  • Published: 2017-09-05

    Issue: Vol 4 No 9 (view)

    Section: Articles

    How to cite:
    Perry, M., Cooper, S., & Corry, S. (2017). Neurosyphilis Presenting with Papillitis. European Journal of Case Reports in Internal Medicine, 4(9).

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