Chlorpyrifos-Induced Delayed Neurotoxicity with A Rare Presentation of Flaccid Quadriplegia: A Diagnostic Challenge
  • Patrícia Afonso Mendes
    Internal Medicine Department A, Centro Hospitalar e Universitário de Coimbra, Coimbra http://orcid.org/0000-0003-0014-965X
  • Tatiana Cunha Pereira
    Oncology Service, Instituto Português de Oncologia de Coimbra Francisco Gentil, Coimbra
  • Rui Pina
    Internal Medicine Department A, Centro Hospitalar e Universitário de Coimbra, Coimbra
  • Rui Marques Santos
    Internal Medicine Department A, Centro Hospitalar e Universitário de Coimbra, Coimbra

Abstract

Chlorpyrifos is an organophosphate compound recognized as causing acute toxicity. However, organophosphate-induced delayed polyneuropathy (OPIDP), although rare, has also been described. We describe an unusual presentation of OPIDP with flaccid quadriplegia progressing to a locked-in-like syndrome, 30 days after a 60-year-old man voluntarily ingested chlorpyrifos. In the absence of specific treatment, the patient only recovered partial motor responses and the ability to communicate. The authors present this report in order to highlight a form of OPIDP which can hinder diagnosis due to its atypia and the delay in the onset of symptoms from initial contact with the toxicant.

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    Published: 2017-10-30
    Issue: Vol. 5 No. 1 (view)

    How to cite:
    1.
    Mendes PA, Pereira TC, Pina R, Santos RM. Chlorpyrifos-Induced Delayed Neurotoxicity with A Rare Presentation of Flaccid Quadriplegia: A Diagnostic Challenge. EJCRIM 2017;5 doi:10.12890/2017_000751.

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