European Journal of Case Reports in Internal Medicine


The European Journal of Case Reports in Internal Medicine is an official journal of the European Federation of Internal Medicine (EFIM). The journal wants to promote the practice of internal medicine in Europe. Its aim is to provide a forum to internal medicine doctors.
EJCRIM welcomes papers describing unusual or complex cases and case series that an internist may encounter in everyday practice. Case series are also welcomed as long as they demonstrate the appropiateness of a therapeutical approach or unusual manifestation of a disease.
The journal would also consider brief reasoned reports of issues relevant to the practice of Internal Medicine, as well as Abstracts submitted to scientific meetings of European societies of Internal Medicine.

EJCRIM is peer-reviewed with single-blind review and freely accessible to all.

Kapil Kumar Garg, Hapreet Singh
Daniela Dias Alves, Nulita Lourenço, Daniela Franco, Eufémio Calmeiro, Rosa Silva
María García-López, Carlos Cárceles-García, Mariya Ovsepyan, Jara Llenas-Garcia
Yogev Peri, Oshrat Tayer Shifman, Alon Hershko
Hana ZOUBEIDI, Thouraya Ben Salem, Imed Ben Ghorbel, Mohamed Habib Houman
Maria Kyriakopoulou, Guy Decaux, Mike El Mourad, Ruben Casado Arroyo
Hana Zoubeidi, Zohra Aydi, Fatma Daoud, Imen Rachdi, Wafa Koubaa, Raja Jouini, Lilia Baili, Achraf Debbiche, Besma Ben Dhaou, Fatma Boussema
Stefania Scarlini, Marco Gandolfo, Antonello Pietrangelo

Two Faces of the Same Coin: A Case Report of Antiphospholipid Syndrome Nephropathy

Sofia Marques, Hugo Ferreira, Ana Teresa Nunes, Roberto Silva, Susana Sampaio
Published: 23/01/2017


Antiphospholipid syndrome (APS) is an autoimmune disease which can be primary or secondary to other autoimmune conditions and is defined by the occurrence of arterial or venous thrombosis, or pregnancy morbidity associated with persistently positive antiphospholipid antibodies (aPLA). The kidney may be affected by thrombosis at any level of its vasculature. When small vessels are involved, this results in thrombotic microangiopathy (TMA), which can manifest as either acute vaso-occlusive or chronic vascular lesions in glomeruli, arterioles and interlobular arteries. We report the case of 26-year-old man, with a previous medical history suggestive of APS, who was found to have a small elevation in serum creatinine. A kidney biopsy was performed and revealed features of chronic TMA. Anticoagulation was begun and kidney function remained stable. However, one year later, upon suspension of anticoagulation, the patient developed acute kidney injury and a second kidney biopsy showed acute TMA. This case describes different manifestations of antiphospholipid syndrome nephropathy (APSN) and highlights the importance of anticoagulation for thrombosis prevention.