Paecilomyces Pneumonia Despite Voriconazole Prophylaxis: A Case Report and Literature Review
  • Abuzar A Asif
    Department of Internal Medicine, University of Illinois College of Medicine at Peoria, OSF Saint Francis Medical Center, Peoria, USA
  • Mony Roy
    Department of Internal Medicine, University of Illinois College of Medicine at Peoria, OSF Saint Francis Medical Center, Peoria, USA
  • Sharjeel Ahamad
    Section of Infectious Diseases, University of Illinois College of Medicine at Peoria, OSF Saint Francis Medical Center, Peoria, USA

Keywords

Paecilomyces, pneumonia, voriconazole, resistance, posaconazole

Abstract

Paecilomyces species are a rare cause of fungal pulmonary infections in immunocompromised hosts. Paecilomyces variotii and Paecilomyces lilacinus are the two most common species of clinical significance. Both species differ in their susceptibility to antifungal agents. We present a rare case of a 47-year-old immunocompromised woman who developed Paecilomyces pneumonia despite being on voriconazole prophylaxis. We also present a review of the literature on other reported cases.

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References

  • Steiner B, Aquino VR, Paz AA, Silla LM, Zavascki A, Goldani LZ. Paecilomyces variotii as an emergent pathogenic agent of pneumonia. Case Rep Infect Dis 2013;2013:273848. https://doi.org/10.1155/2013/273848
  • Gutiérrez F, Masiá M, Ramos JM, Elía M, Rodríguez-Tudela JL, Cuenca-Estrella M. Lack of efficacy of voriconazole therapy in 2 patients with pulmonary fungus balls. Clin Infect Dis 2005;40(11):1706–1707. https://doi.org/10.1086/430176
  • Feldman R, Cockerham L, Buchan BW, Lu Z, Huang AM. Treatment of Paecilomyces variotii pneumonia with posaconazole: case report and literature review. Mycoses 2016;59(12):746–750. https://doi.org/10.1111/myc.12525
  • Marques DP, Carvalho J, Rocha S, Domingos R. A case of pulmonary mycetoma caused by Paecilomyces variotii. Eur J Case Rep Intern Med 2019;6(2):001040. https://doi.org/10.12890/2019_001040
  • Chamilos G, Kontoyiannis DP. Voriconazole-resistant disseminated Paecilomyces variotii infection in a neutropenic patient with leukaemia on voriconazole prophylaxis. J Infect 2005;51(4):e225–228. https://doi.org/10.1016/j.jinf.2005.02.005
  • Castelli MV, Alastruey-Izquierdo A, Cuesta I, Monzon A, Mellado E, Rodriguez-Tudela JL, Cuenca-Estrella M. Susceptibility testing and molecular classification of Paecilomyces spp. Antimicrob Agents Chemother 2008;52(8):2926–2928. https://doi-org.proxy.cc.uic.edu/10.1128/AAC.00538-08

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    Published: 2021-06-21
    Issue: 2021: Vol 8 No 6 (view)

    How to cite:
    1.
    Asif AA, Roy M, Ahamad S. Paecilomyces Pneumonia Despite Voriconazole Prophylaxis: A Case Report and Literature Review. EJCRIM 2021;8 doi:10.12890/2021_002651.