Keywords
Cutaneous necrosis, antiphospholipid syndrome, cryoglobulinaemia
Abstract
A 23-year-old woman, a smoker and oral oestrogen user, presented with nasal necrosis. No other symptoms or local trauma were described. Relevant laboratory findings included complement consumption, positive lupus-anticoagulant assay, increased rheumatoid factor and positive cryoglobulins. Screening for autoimmune conditions, haematological malignancies and infectious diseases was negative. Histological examination of the nasal skin showed small vessel occlusion without vasculitis. Later, a second positive lupus-anticoagulant assay supported the diagnosis of antiphospholipid syndrome. The patient improved with glucocorticoids and anticoagulation. This case report describes an unusual manifestation of antiphospholipid syndrome in a patient with cryoglobulinaemia contributing to the thrombotic event and highlights the importance of recognizing these overlapping disorders.
References
Views: 1310
HTML downloads: 4335
PDF downloads: 376
Figure 1. downloads: 0
Figure 2. downloads: 0
Figure 3. downloads: 0
Figure 4. downloads: 0
Clinical image description downloads: 0
Published:
2017-03-27
Issue:
Vol. 4 No. 2
(view)