Severe Acquired Coagulopathy During Fulminant Staphylococcus aureus Sepsis Most Likely Caused by S. aureus Exotoxins (SSLs)
  • Lonneke Draaijers
    Rijnstate Arnhem
  • Robert-Jan Hassing
    Internal Medicine, Infectious Diseases, Rijnstate Hospital Arnhem, The Netherlands
  • Menno Kooistra
    Internal Medicine, Nephrology, Rijnstate Hospital Arnhem, The Netherlands
  • KoK van Kessel
    Medical Microbiology, University Medical Center Utrecht, The Netherlands
  • Marcel Hovens
    Internal Medicine, Vascular Medicine, Rijnstate Hospital Arnhem, The Netherlands


Staphylococcus aureus, coagulopathy, staphylococcal superantigen-like protein, coagulation factor Xa, disseminated intravascular coagulation


Haemostatic abnormalities frequently occur during sepsis and are most often attributed to disseminated intravascular coagulation (DIC). We report the case of a patient with severe coagulopathy acquired during fulminant S. aureus sepsis. DIC was not present. This coagulopathy was most likely caused by S. aureus exotoxins forming inhibitory complexes with coagulation factor Xa.



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    Published: 2018-12-27
    Issue: Vol 5 No 12 (view)

    How to cite:
    Draaijers L, Hassing R-J, Kooistra M, van Kessel K, Hovens M. Severe Acquired Coagulopathy During Fulminant Staphylococcus aureus Sepsis Most Likely Caused by S. aureus Exotoxins (SSLs). EJCRIM 2018;5 doi:10.12890/2018_001002.

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