Late-Onset Rash from Irbesartan: An Immunological Reaction
  • Bárbara Kong Cardoso
    Centro Hospitalar de Setúbal, Serviço de Imunoalergologia, Setúbal, Portugal
  • Marta Martins
    Centro Hospitalar de Setúbal, Serviço de Imunoalergologia, Setúbal, Portugal
  • Sofia Martins Farinha
    Centro Hospitalar de Setúbal, Serviço de Imunoalergologia, Setúbal, Portugal
  • Regina Viseu
    Centro Hospitalar de Setúbal, Serviço de Imunoalergologia, Setúbal, Portugal
  • Elza Tomaz
    Centro Hospitalar de Setúbal, Serviço de Imunoalergologia, Setúbal, Portugal
  • Filipe Inácio
    Centro Hospitalar de Setúbal, Serviço de Imunoalergologia, Setúbal, Portugal

Keywords

Irbesartan allergy, maculopapular rash, patch tests, lymphocyte transformation test, drug reaction

Abstract

Cutaneous delayed reactions to antihypertensive drugs have been described in a limited number of case reports but the mechanisms remain mostly unknown. We report the case of a 60-year-old female patient with a 3-week history of an itchy erythematous maculopapular eruption. Although the patient was polymedicated, irbesartan was the most likely culprit. Patch tests and a lymphocyte transformation test to irbesartan were both positive, which was useful for diagnosis and suggested an immunological reaction. No new lesions appeared after irbesartan was stopped or after the introduction of candesartan. Despite its similar chemical structure, candesartan may be tried in patients allergic to irbesartan.

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    Published: 2019-06-19
    Issue: Vol 6 No 6 (view)


    How to cite:
    1.
    Kong Cardoso B, Martins M, Martins Farinha S, Viseu R, Tomaz E, Inácio F. Late-Onset Rash from Irbesartan: An Immunological Reaction. EJCRIM 2019;6 doi:10.12890/2019_001128.