A Paraneoplastic Syndrome to Remember: A Case of Disseminated Intravascular Coagulation in Lung Cancer

  • Rita de Sousa Gameiro Internal Medicine, Hospital Beatriz Ângelo, Loures, Portugal
  • Rodolfo Gomes Internal Medicine, Hospital Beatriz Ângelo, Loures, Portugal
  • Vanda Jorge Internal Medicine, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal
  • Bárbara Sousa Picado Internal Medicine, Hospital Beatriz Ângelo, Loures, Portugal
  • Fernando Martos Gonçalves Internal Medicine, Hospital Beatriz Ângelo, Loures, Portugal
  • José Lomelino Araújo Internal Medicine, Hospital Beatriz Ângelo, Loures, Portugal

Keywords

Disseminated intravascular coagulation, lung cancer, intracerebral bleeding

Abstract

Disseminated intravascular coagulation (DIC) is an acquired syndrome characterized by the widespread activation of coagulation. It can present as an acute life-threatening emergency or as a chronic process. Mortality is highly dependent on the reversibility of the aetiology and degree of coagulation impairment, so treatment of the underlying cause is vital. The authors present the case of a 57-year-old man whose inaugural presentation of lung cancer was chronic DIC, characterized by three thrombotic events, followed by acute DIC, culminating in death. Metastatic lung cancer was diagnosed only after death.

References

  • Sallah S, Wan JY, Nguyen NP, et al. Disseminated intravascular coagulation in solid tumours: clinical and pathologic study. Thromb Haemost 2001;86:828.

  • Levi M, Toh CH, Thachil J, et al. Guidelines for the diagnosis and management of disseminated intravascular coagulation. Br J Haematol2009;145:24–33.

  • World Health Organization. Top 10 causes of death. 2016. https://www.who.int/gho/mortality_burden_disease/causes_death/top_10/en/ (accessed 3 April 2019).

  • Falanga A, Russo L, Milesi V, et al. Mechanisms and risk factors of thrombosis in cancer. Crit Rev Oncol Hematol 2017;118:79–83.

  • Wada H, Thachil J, Di Nisio M, et al. Guidance for diagnosis and treatment of disseminated intravascular coagulation from harmonization of the recommendations from three guidelines. J Thromb Haemost 2013;11:761–767.

  • Leung L. Clinical features, diagnosis, and treatment of disseminated intravascular coagulation in adults. UpToDate. https://www.uptodate.com/contents/clinical-features-diagnosis-and-treatment-of-disseminated-intravascular-coagulation-in-adults (accessed 3 April 2019).

  • Di Nisio M, Baudo F, Cosmi B, et al. Diagnosis and treatment of disseminated intravascular coagulation: guidelines of the Italian Society for Haemostasis and Thrombosis (SISET). Thromb Res 2012;129:e177–e184.

  • Nakano K, Sugiyama K, Satoh H, et al. Effect of thrombomodulin alfa on disseminated intravascular coagulation in patients with lung cancer. Intern Med 2017;56:1799–1806.
  • Published: 2019-06-03

    Issue: LATEST ONLINE (view)

    Section: Articles

    How to cite:
    Gameiro, R., Gomes, R., Jorge, V., Picado, B., Gonçalves, F., & Araújo, J. (2019). A Paraneoplastic Syndrome to Remember: A Case of Disseminated Intravascular Coagulation in Lung Cancer. European Journal of Case Reports in Internal Medicine, 2. https://doi.org/https://doi.org/10.12890/2019_001134