Olmesartan: A Little-Known Cause of Diarrhoea

  • Joana Serôdio Internal Medicine Department, Unidade Local de Saúde do Alto Minho, Portugal
  • Joana Carneiro Internal Medicine Department, Unidade Local de Saúde do Alto Minho, Portugal
  • Manuel Veiga Anatomical Pathology Department, Unidade Local de Saúde do Alto Minho, Portugal
  • António Ferreira Internal Medicine Department, Unidade Local de Saúde do Alto Minho, Portugal

Keywords

Olmesartan, diarrhoea, villous atrophy

Abstract

Olmesartan's sprue-like enteropathy was first described in 2012 and typically presents with diarrhoea, weight loss, nausea, vomiting, low albumin and histological evidence of intestinal villous atrophy. Coeliac disease is one of the main differential diagnoses and should be excluded. We present the clinical case of a 63-year-old man treated with olmesartan for 10 years who presented with a 2-month history of diarrhoea and was diagnosed with olmesartan´s enteropathy. This case highlights the need for clinical suspicion of this new entity in order to reduce the associated morbidity and unnecessary costly investigations.

VIEW THE ENTIRE ARTICLE

References

  • Rubio-Tapia A, Herman ML, Ludvigsson JF, Kelly D, Mangan T, Wu T, et al. Spruelike enteropathy associated with olmesartan. Mayo Clin Proc 2012;87(8):732–738.

  • Jansson-Knodell CL, Hujoel IA, Rubio-Tapia A, Murray JA. Not all that flattens villi is celiac disease: a review of enteropathies. Mayo Clin Proc 2018;93(4):509–517.

  • DeGaetani M, Tennyson CA, Lebwohl B, Lewis SK, Abu Daya H, Arguelles-Grande C, et al. Villous atrophy and negative celiac serology: a diagnostic and therapeutic dilemma. Am J Gastroenterol 2013;108:647–653.

  • Adike A, Corral J, Rybnicek D, Sussman D, Shah S, Quigley E. Olmesartan-induced enteropathy. Methodist Debakey Cardiovasc J 2016;12(4):230–232.

  • Laniro G, Bibbò S, Montalto M, Ricci R, Gasbarrini A, Cammarota G. Systematic review: sprue-like enteropathy associated with olmesartan. Aliment Pharmacol Ther 2014;40:16–23.
  • Published: 2019-06-28

    Issue: Vol 6 No 7 (view)

    Section: Articles

    How to cite:
    1.
    Serôdio J, Carneiro J, Veiga M, Ferreira A. Olmesartan: A Little-Known Cause of Diarrhoea. EJCRIM 2019;6 doi:10.12890/2019_001143.