Fever During Anti-integrin Therapy: New Immunodeficiency
  • Eleonora Bonfanti
    Department of Internal Medicine, "Santa Croce e Carle" Hospital, Cuneo
  • Christian Bracco
    Department of Internal Medicine, "Santa Croce e Carle" Hospital, Cuneo, Italy
  • Paolo Biancheri
    Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, United Kingdom
  • Andrea Falcetta
    Department of Internal Medicine, "Santa Croce e Carle" Hospital, Cuneo, Italy
  • Marco Badinella Martini
    Department of Internal Medicine, "Santa Croce e Carle" Hospital, Cuneo, Italy
  • Remo Melchio
    Department of Internal Medicine, "Santa Croce e Carle" Hospital, Cuneo, Italy


Vedolizumab, cytomegalovirus, ulcerative colitis


Background: The causes of inflammatory bowel disease (IBD) have not yet been clearly elucidated, but it is known that genetic susceptibility, altered gut microbiota and environmental factors are all involved, and that a combination of these factors causes an inappropriate immune response, resulting in impaired intestinal barrier function. With regard to the treatment of IBD, the use of conventional immunosuppressive drugs has been complemented by more specific therapeutic agents, including biological drugs. Systemic immune suppression is a risk factor for cytomegalovirus (CMV) infection, which is associated with considerable morbidity and mortality in immunocompromised hosts.
Case Report: A 33-year-old male patient was admitted to our medical unit complaining of a 10-day history of fever, fatigue and headache. He had been suffering from ulcerative colitis and primary sclerosing cholangitis for five years and was currently being treated with azathioprine and vedolizumab. In the past he had already taken infliximab, adalimumab and golimumab without any clinical response. After the exclusion of systemic infectious diseases, his serology was consistent with a primary CMV infection. This was successfully treated with intravenous ganciclovir therapy.
Conclusion: Vedolizumab is an anti-integrin biological agent approved for IBD treatment. Its gut-selective mechanism of action would appear to increase its safety profile, however data on this are still limited. Moreover, it should always be remembered that IBD patients have an increased risk of CMV infection, both primary and reactivation, because of their concurrent immunosuppression.



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    Published: 2020-02-11
    Issue: 2020: Vol 7 No 3 (view)

    How to cite:
    Bonfanti E, Bracco C, Biancheri P, Falcetta A, Badinella Martini M, Melchio R. Fever During Anti-integrin Therapy: New Immunodeficiency. EJCRIM 2020;7 doi:10.12890/2020_001288.