Severe Acute Dyspnoea of Extra-Thoracic Origin: Experience with Three Primary Thyroid Lymphomas (PTL)
  • Adrienne Grueber
    Clinic of Medicine, Departments of Oncology and Endocrinology, HFR Fribourg-Hôpital Cantonal, Fribourg
  • Sophie Zürcher
    Clinic of Medicine, Department of Endocrinology, HFR Fribourg-Hôpital Cantonal, Fribourg
  • Daniel Charles Betticher
    Clinic of Medicine, Departments of Oncology and Endocrinology, HFR Fribourg-Hôpital Cantonal, Fribourg
  • Enzo Fontana
    Clinic of Medicine, Department of Endocrinology, HFR Fribourg-Hôpital Cantonal, Fribourg

Abstract

Objectives: To recall the common clinical presenting features of and guide the diagnostic procedures of primary thyroid lymphomas (PTL).

Materials and methods: We report on three patients developing an acute dyspnoea and fast evolving neck mass in the thyroid caused by a PTL occurring in our regional hospital in Switzerland between 2009 and 2013.

Results: PTL causes a neck mass, dyspnoea and dysphonia and responds well to chemotherapy. Mortality is due to relapse or infectious complications.

Conclusion: Acute dyspnoea caused by thyroid disease is uncommon. Nevertheless, it is the main symptom in PTL due to rapid growth and compression of the airways. Chemotherapy should be started promptly.

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References

  • Pedersen RK, Pedersen NT. Primary non-Hodgkin lymphoma of the thyroid gland: a population based study, Histopathology 1996;28:25–32.
  • Derringer GA, Thompson LD, Frommelt RA, Bijwaard KE, Heffess CS, Abbondanzo SL. Malignant lymphoma of the thyroid gland: a clinicopathologic study of 108 cases, Am J Surg Pathol 2000;24:623–639.
  • Stein SA, Wartofsky L. Primary thyroid lymphoma: a clinical review, J Clin Endocrinol Metab 2013;98:3131–3138.
  • Ghielmini M, Vitolo U, Kimby E, Montoto S, Walewski J, Pfreundschuh M et al. ESMO Guidelines Consensus Conference on Malignant Lymphoma 2011. Part 1: diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and chronic lymphocytic leukemia (CLL), Ann Oncol 2013;24:561–576.
  • Dreyling M, Thieblemont C, Gallamini A, Arcaini L, Campo E, Hermine O et al. ESMO Consensus Conferences: guidelines on malignant lymphoma part 2: marginal zone lymphoma, mantle cell lymphoma, peripheral T-cell lymphoma, Ann Oncol 2013;24:857–877.
  • Onal C, Li YX, Miller RC, Poortmans P, Constantinou N, Weber DC et al. Treatment results and prognostic factors in primary thyroid lymphoma patients: a rare cancer network study, Ann Oncol 2011;22:156–164.
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    Published: 2014-10-22
    Issue: Vol. 1 (2014) (view)


    How to cite:
    1.
    Grueber A, Zürcher S, Betticher DC, Fontana E. Severe Acute Dyspnoea of Extra-Thoracic Origin: Experience with Three Primary Thyroid Lymphomas (PTL). EJCRIM 2014;1 doi:10.12890/2014_000136.