Reactive Arthritis – A Rare Complication of Intravesical BCG Instillation
  • Marta Freixa
    Department of Internal Medicine, Hospital Pulido Valente, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal
  • Sara Úria
    Department of Internal Medicine, Hospital Pulido Valente, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal
  • Glória Nunes da Silva
    Department of Internal Medicine, Hospital Pulido Valente, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal

Keywords

Reactive arthritis, intravesical Bacillus Calmette-Guérin, carcinoma in situ of the bladder

Abstract

Reactive arthritis (ReA) with the classic triad of arthritis, conjunctivitis and urethritis, previously termed Reiter’s syndrome, is a systemic illness, usually induced by genitourinary or gastrointestinal infections. However, it can be a rare complication of intravesical Bacillus Calmette-Guérin instillation (iBCG), a therapy prepared from attenuated strains of Mycobacterium bovis, a common and effective treatment for carcinoma in situ of the bladder (CisB). We report a case of a patient with CisB who developed ReA after iBCG. The symptoms resolved completely with corticosteroids. iBCG was stopped with no recurrence of carcinoma within 2 years.

VIEW THE ENTIRE ARTICLE

References

  • García-Kutzbach A, Chacón-Súchite J, García-Ferrer H, Iraheta I. Reactive arthritis: update 2018. Clin Rheumatol 2018;374):869–874.

  • Bernini L, Manzini CU, Giuggioli D, Sebastiani M, Ferri C. Reactive arthritis induced by intravesical BCG therapy for bladder cancer: our clinical experience and systematic review of the literature. Autoimmun Rev 2013;12(12):1150–1159.

  • Nakagawa T, Shigehara K, Naito R, Yaegashi H, Nakashima K, Iijima M, et al. Reiter’s syndrome following intravesical Bacillus Calmette-Guerin therapy for bladder carcinoma: a report of five cases. Int Cancer Conf J 2018;7(4):148–151.

  • Ben Abdelghani K, Fazaa A, Souabni L, Zakraoui L. Reactive arthritis induced by intravesical BCG therapy for bladder cancer. BMJ Case Rep 2014;2014:bcr2013202741.
  • Views: 912
    HTML downloads: 67
    PDF downloads: 531


    Published: 2020-02-04
    Issue: 2020: Vol 7 No 3 (view)


    How to cite:
    1.
    Freixa M, Úria S, da Silva GN. Reactive Arthritis – A Rare Complication of Intravesical BCG Instillation. EJCRIM 2020;7 doi:10.12890/2020_001448.