COVID-19 and Pulmonary Embolism: Not a Coincidence
  • Adriana Tamburello
    General Internal Medicine, Ospedale Regionale di Lugano, Switzerland
  • Giovanni Bruno
    General Internal Medicine, Ospedale Regionale di Lugano, Switzerland
  • Marco Marando
    General Internal Medicine, Ospedale Regionale di Lugano, Switzerland

Keywords

Coronavirus, COVID-19, SARS-CoV-2, pulmonary embolism, coagulation abnormalities, tocilizumab

Abstract

In December 2019, a novel coronavirus called SARS-CoV-2 was reported to be responsible for a cluster of acute atypical respiratory pneumonia cases in Wuhan, in Hubei province, China. The disease caused by this virus is called COVID-19 (coronavirus disease 2019). The virus is transmitted between humans and the outbreak was declared a pandemic by the World Health Organization (WHO) on 11 March 2020. Coagulopathy is a common abnormality in patients with COVID?19 due to inflammation, hypoxia, immobilisation, endothelial damage and diffuse intravascular coagulation. However, the data on this topic are still limited. Here we report the case of a man presenting with pneumonia complicated by bilateral pulmonary embolism.

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References

  • Lu H, Stratton CW, Tang YW. Outbreak of pneumonia of unknown etiology in Wuhan, China: the mystery and the miracle. J Med Virol 2020;92:401–402.

  • Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al.; China Novel Coronavirus Investigating and Research Team. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 2020;382:727–773.

  • Marando M, Tamburello A, Gianella P. False-negative nasopharyngeal swab RT-PCR assays in typical COVID-19: role of ultra-low-dose chest CT and bronchoscopy in diagnosis. Eur J Case Rep Intern Med 2020.
  • https://doi.org/https://doi.org/10.12890/2020_001680.
  • Chan Jasper Fuk-Woo, Yuan Shuofeng, Kok Kin-Hang, To Kelvin Kai-Wang, Chu Hin, Yang Jin. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet 2020;395:514–523.

  • Lechien JR, Chiesa-Estomba CM, De Siati DR, Horoi M, Le Bon SD, Rodriguez A, et al. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur Arch Otorhinolaryngol 2020 Apr 6. doi: 10.1007/s00405-020-05965-1 [Epub ahead of print].

  • Tamburello A, Marando M. Immunoglobulins or convalescent plasma to tackle COVID-19: buying time to save lives-current situation and perspectives. Swiss Med Wkly 2020;150:w20264 doi: https://doi.org/10.4414/smw.2020.20264

  • Han H, Yang L, Liu R, Liu F, Wu KL. Prominent changes in blood coagulation of patients with SARS-CoV-2 infection. Clin Chem Lab Med 2020 Mar 16. pii: /j/cclm.ahead-of-print/cclm-2020-0188/cclm-2020-0188.xml. doi: 10.1515/cclm-2020-0188 [Epub ahead of print].

  • Chen T, Wu D, Chen H, Yan W, Yang D. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ 2020;368:m1091.

  • Rotzinger DC, Beigelman-Aubry C, von Garnier C, Qanadli SD. Pulmonary embolism in patients with COVID-19: time to change the paradigm of computed tomography. Thromb Res 2020;190:58–59.

  • Cellina M, Orsi M, Bombaci F, Sala M, Marino P, Oliva G. Favorable changes of CT findings in a patient with COVID-19 pneumonia after treatment with tocilizumab. Diagn Interv Imaging 2020 Mar 31. pii: S2211-5684(20)30087-5. doi: 10.1016/j.diii.2020.03.010 [Epub ahead of print].

  • Han H, Yang L, Liu R, Liu F, Wu KL. Prominent changes in blood coagulation of patients with SARS-CoV-2 infection. Clin Chem Lab Med 2020 Mar 16. pii: /j/cclm.ahead-of-print/cclm-2020-0188/cclm-2020-0188.xml. doi: 10.1515/cclm-2020-0188 [Epub ahead of print].

  • Danzi GB, Loffi M, Galeazzi G, Gherbesi E. Acute pulmonary embolism and COVID-19 pneumonia: a random association? Eur Heart J 2020 Mar 30. pii: ehaa254. doi: 10.1093/eurheartj/ehaa254 [Epub ahead of print].

  • Zhai Z, Li C, Chen Y, Gerotziafas G. Prevention and treatment of venous thromboembolism associated with coronavirus disease 2019 infection: a consensus statement before guidelines. Thromb Haemost 2020 Apr 21. doi: 10.1055/s-0040-1710019 [Epub ahead of print].

  • Ciceri F, Beretta L, Scandroglio AM, Colombo S, Landoni G, Ruggeri A, et al. Microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome (MicroCLOTS): an atypical acute respiratory distress syndrome working hypothesis. Crit Care Resusc 2020 Apr 15 [Epub ahead of print].

  • Varga Z, Flammer AJ, Steiger P, Haberecker M, Andermatt R, Zinkernagel AS, et al. Endothelial cell infection and endotheliitis in COVID-19. Lancet 2020 Apr 20. pii: S0140-6736(20)30937-5. doi: 10.1016/S0140-6736(20)30937-5 [Epub ahead of print].

  • Feldmann M, Maini RN, Woody JN, Holgate ST, Winter G, Rowland M, et al. Trials of anti-tumour necrosis factor therapy for COVID-19 are urgently needed. Lancet 2020 Apr 9. pii: S0140-6736(20)30858-8. doi: 10.1016/S0140-6736(20)30858-8 [Epub ahead of print].
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    Published: 2020-05-04
    Issue: 2020: Vol 7 No 6 (view)


    How to cite:
    1.
    Tamburello A, Bruno G, Marando M. COVID-19 and Pulmonary Embolism: Not a Coincidence. EJCRIM 2020;7 doi:10.12890/2020_001692.