Thyroid Storm Associated with Testicular Choriocarcinoma
  • Julio César Martínez
    Internal Medicine Department, University Hospital “Dr. Gonzalo Valdés”, Universidad Autónoma de Coahuila, Saltillo, Coahuila, Mexico
  • Ernesto Alfonso Ovalle-Zavala
    Faculty of Medicine, Universidad Autónoma de Coahuila, Saltillo, Coahuila, Mexico

Keywords

Thyroid storm, testicular choriocarcinoma, human chorionic gonadotropin

Abstract

Thyroid storm is a rare, life-threatening condition that can be caused by various pathologies including serious conditions associated with human chorionic gonadotropin (hCG)-producing tumours.
We present the case of a 17-year-old male patient with a 1-month history of dyspnoea and a 3-day history of palpitations and fever. General examination revealed a left testicular mass. Blood tests revealed ?-hCG >225,000 mIU/ml, thyroid-stimulating hormone (TSH) 0.02 IU/ml, and thyroxine (T4) 19.07 µg/dl. He was admitted with thyroid storm. Treatment with antithyroid drugs and chemotherapy was started, but the patient died on the third day of admission.
This case highlights a rare occurrence of thyroid storm linked to testicular choriocarcinoma, and provides a necessary reminder that, in some instances, hCG at very high levels can exert a thyrotropic effect due to its molecular structure, which is similar to that of TSH.

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    Published: 2020-07-02
    Issue: 2020: Vol 7 No 10 (view)


    How to cite:
    1.
    Martínez JC, Ovalle-Zavala EA. Thyroid Storm Associated with Testicular Choriocarcinoma. EJCRIM 2020;7 doi:10.12890/2020_001754.