Pleural Effusion Related to Chronic Hepatitis B Virus Reactivation: A Rare Association
  • Ana Oliveira
    erviço de Medicina Interna, Centro Hospitalar Universitário do Porto, Porto, Portugal
  • Diana Valadares
    Unidade de Cuidados Intermédios Médicos, Serviço de Cuidados Intensivos, Centro Hospitalar Universitário do Porto, Porto, Portugal
  • Filipe Nery
    Unidade de Cuidados Intermédios Médicos, Serviço de Cuidados Intensivos, Centro Hospitalar Universitário do Porto, Porto, Portugal; Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal; EpiUnit, Instituto de Saúde Pública da Universidade do Porto, Porto, Portugal


Hepatitis B virus, viral reactivation, extrahepatic manifestations, Pleural effusion


Despite worldwide vaccination campaigns, hepatitis B virus (HBV) infection remains a major public health problem. The natural history ranges from asymptomatic infection to severe liver injury or failure, chronic complications or reactivation episodes. The effects of HBV on the organism are immunomediated, possibly triggering extrahepatic manifestations. Since 1971, only a few cases of pleural effusion related to HBV infection have been described. We report HBV-associated pleural effusion occurring during a viral reactivation episode. Antiviral treatment directed towards pleural effusion related to HBV infection should be dictated by underlying liver disease severity and not pleural effusion severity.



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    Published: 2021-02-12
    Issue: 2021: Vol 8 No 2 (view)

    How to cite:
    Oliveira A, Valadares D, Nery F. Pleural Effusion Related to Chronic Hepatitis B Virus Reactivation: A Rare Association. EJCRIM 2021;8 doi:10.12890/2021_002270.