Persistent Antiphospholipid Antibodies, Mast Cell Activation Syndrome, Postural Orthostatic Tachycardia Syndrome and Post-COVID Syndrome: 1 Year On
  • Jill Schofield
    University of Colorado School of Medicine, Aurora, Colorado, USA


Long-haul COVID-19, antiphospholipid antibodies, postural orthostatic tachycardia syndrome, mast cell activation syndrome, post-COVID syndrome


This is the first case report of a patient with post-COVID-19 postural orthostatic tachycardia syndrome (POTS) with multiple persistent antiphospholipid antibody (aPL)-positivity more than a year after illness onset who also meets Global Consensus-2 criteria for mast cell activation syndrome (MCAS), suggesting pathological activation of the acquired and innate immune systems by SARS-CoV-2. While the patient continues to meet criteria for POTS 1 year on, her functional ability has improved significantly with therapy directed at MCAS, POTS and aPL-positivity.




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    Published: 2021-03-22
    Issue: 2021: Vol 8 No 3 (view)

    How to cite:
    Schofield J. Persistent Antiphospholipid Antibodies, Mast Cell Activation Syndrome, Postural Orthostatic Tachycardia Syndrome and Post-COVID Syndrome: 1 Year On. EJCRIM 2021;8 doi:10.12890/2021_002378.