Delayed Recognition of Levetiracetam-induced Pancytopenia
  • Mohammad Ammad Ud Din
    Internal Medicine, Rochester General Hospital, Rochester, New York, USA
  • Syed Ather Hussain
    Internal Medicine, Rochester General Hospital, Rochester, New York, USA
  • Amy Bodrog
    Hematology/Oncology, Rochester General Hospital, Rochester, New York, USA


Drug-induced-pancytopenia, thrombocytopenia, levetiracetam, hematology, anti-epileptics


Blood dyscrasias associated with levetiracetam use can be difficult to identify, especially when other potential differential diagnoses are concurrently present. Here we present a 57-year-old man with metastatic adenocarcinoma of unknown primary origin on levetiracetam who initially presented with an in-stent thrombosis of the right external iliac vein and then developed worsening thrombocytopenia followed by pancytopenia. Levetiracetam was not identified as the culprit until other causes like platelet consumption, heparin-induced thrombocytopenia, idiopathic immune thrombocytopenic purpura, and bone marrow involvement by metastatic disease were ruled out.



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    Published: 2021-03-30
    Issue: 2021: Vol 8 No 3 (view)

    How to cite:
    Ammad Ud Din M, Ather Hussain S, Bodrog A. Delayed Recognition of Levetiracetam-induced Pancytopenia. EJCRIM 2021;8 doi:10.12890/2021_002449.

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