Bowel Perforation During Haemophagocytic Lymphohistiocytosis Treatment with Corticosteroids and Anakinra
  • Jan Adamski
    Department of Anaesthesiology and Intensive Care, Faculty of Medical Sciences, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland
  • Björn Jäschke
    Department of Anaesthesiology and Intensive Care, Satakunta Central Hospital, Pori, Finland
  • Tuomas Nieminen
    Department of Infectious Diseases, Satakunta Central Hospital, Pori, Finland
  • Wojciech Weigl
    Anaesthesiology and Intensive Care, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden


Diverticulitis, haemophagocytic lymphohistiocytosis (HLH), gut, interkeukin-1 (IL-1) receptor antagonist, gastrointestinal diseases


We report the use of anakinra to treat a case of a 64-year-old man diagnosed with hemophagocytic lymphohistiocytosis (HLH) with neurological involvement. After the administration of intravenous pulse corticosteroid therapy, immunoglobulin, and anakinra, the patient showed neurological recovery. However, the recovery was complicated by the perforation of a pre-existing bowel diverticulum. The effect of anakinra on bowel inflammation has not yet been clearly established. It can potentially augment bowel inflammation and contribute to the risk of bowel perforation associated with the concomitant use of corticosteroids.



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    Published: 2021-10-12
    Issue: 2021: Vol 8 No 10 (view)

    How to cite:
    Adamski J, Jäschke B, Nieminem T, Weigl W. Bowel Perforation During Haemophagocytic Lymphohistiocytosis Treatment with Corticosteroids and Anakinra. EJCRIM 2021;8 doi:10.12890/2021_002842.