IgG4-Related Disease Affecting Testicle and Myelodysplastic Syndrome: Just a Coincidence?
  • Carla Alvarez Gonzalez
    Department of Internal Medicine, Hospital Universitario Virgen de la Victoria, Málaga, Spain
  • Juan Luis Carrillo Linares
    Department of Internal Medicine, Hospital Universitario Virgen de la Victoria, Málaga, Spain
  • Isabel García Muñoz
    Department of Pathological Anatomy, Hospital Universitario Virgen de la Victoria, Málaga, Spain
  • Andrea Escalona García
    Department of Pathological Anatomy, Hospital Universitario Virgen de la Victoria, Málaga, Spain
  • Pedro Valdivielso
    Department of Internal Medicine, Hospital Universitario Virgen de la Victoria, Málaga, Spain; Faculty of medicine, University of Malaga, Malaga, Spain

Keywords

Immunoglobulin G4-related disease, IgG4-RD, myelodysplastic syndrome, testicle

Abstract

Immunoglobulin G4-related disease (IgG4-RD) is progressive immune-mediated fibrotic condition characterised by a tendency to form tumefactive lesions in different organs and by elevated IgG4 serum concentrations. Urological manifestations are rare and normally occur together with other systemic affections. Myelodysplastic syndromes (MDS) are hematopoietic stem cell neoplasms, with different subtypes based on the type of blood cells involved. MDS can be associated with other pathologies or medical treatments. We present an uncommon case of testicular manifestation associated with myelodysplastic syndrome here.

VIEW THE ENTIRE ARTICLE

References

  • Perugino CA, Stone JH. IgG4-related disease: an update on pathophysiology and implications for clinical care. Nat Rev Rheumatol 2020;16(12):702–714.
  • de Buy Wenniger LM, Scheltema JM, Verheij J, Beuers U. Testicular inflammation as a new manifestation of IgG4-associated disease. Urology 2013;82(2):e15–16.
  • Tokura Y, Kobayashi M, Kusakabe T, Kamai T. Case of hydrocele testis caused by vaginalitis, a rare manifestation of immunoglobulin G4-related disease. Int J Urol 2017;24(10):771–773.
  • Lal J, Bhat S, Doddamani S, Devi L. Isolated testicular immunoglobulin G4-related disease: a mimicker of malignancy. Indian J Urol 2016;32(4):326–328.
  • Tabata R, Tabata C, Okamoto T, Omori K, Terada M, Nagai T. Autoimmune pancreatitis associated with myelodysplastic syndrome. Int Arch Allergy Immunol 2010;151(2):168–172.
  • Matsumoto N, Hishikawa N, Ikegami K, Sato K, Omote Y, Takemoto M, et al. A unique case of encephalopathy with an elevated IgG-4 and extremely high interleukin-6 level and delayed myelodysplastic syndrome. Intern Med 2021;60(13):2125–2128.
  • Views: 465
    HTML downloads: 101
    PDF downloads: 296


    Published: 2021-12-28
    Issue: 2021: Vol 8 No 12 (view)


    How to cite:
    1.
    Alvarez Gonzalez C, Carrillo Linares JL, García Muñoz I, Escalona García A, Valdivielso P. IgG4-Related Disease Affecting Testicle and Myelodysplastic Syndrome: Just a Coincidence?. EJCRIM 2021;8 doi:10.12890/2021_002981.