Secukinumab, Pituitary Enlargement and Panhypopituitarism: Are They Related?

  • Diogo Ramalho Endocrinology Department, Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal
  • André Araújo Neuroradiology Department, Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal
  • Gustavo Rocha Endocrinology Department, Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal
  • Filipa Duarte-Ribeiro Internal Medicine Department, Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal
DOI: https://doi.org/10.12890/2021_003099

Keywords

Pituitary neoplasms, hypophysitis, hypopituitarism, secukinumab

Abstract

Pituitary adenomas are the most common cause of hypopituitarism associated with pituitary enlargement, but other aetiologies have been emerging, namely immune checkpoint inhibitor-induced hypophysitis (ipilimumab, nivolumab and pembrolizumab). Secukinumab is a recently approved human monoclonal antibody used for the treatment of psoriasis, with no know reported cases of hypophysitis. We describe a challenging case of panhypopituitarism in a patient with a pituitary incidentaloma and a temporal relationship between secukinumab initiation and the manifestation of clinical features suggestive of hypopituitarism. In such intricate work-up, the differential diagnoses should be carefully considered, taking into account the therapeutic and prognostic implications.

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    • Published: 2021-12-31

    Issue: 2021: Vol 8 No 12 (view)

    Section: Articles

    How to cite:
    1.
    Ramalho D, Araújo A, Rocha G, Duarte-Ribeiro F. Secukinumab, Pituitary Enlargement and Panhypopituitarism: Are They Related?. EJCRIM 2021;8 doi:10.12890/2021_003099.