Alkaline Diuresis as Treatment for 2,4-D Dimethylamine Herbicide Intoxication
  • Apolonia Berenika Badu
    Bajawa Regional General Hospital, Ngada, East Nusa Tenggara, Indonesia
  • Ade Ajeng Cempakadewi
    Bajawa Regional General Hospital, Ngada, East Nusa Tenggara, Indonesia https://orcid.org/0000-0003-0967-6165
  • Brigitta Marcia Budihardja
    Bajawa Regional General Hospital, Ngada, East Nusa Tenggara, Indonesia https://orcid.org/0000-0003-3468-6314
  • Anselmus Ake
    Bajawa Regional General Hospital, Ngada, East Nusa Tenggara, Indonesia

Keywords

Herbicide intoxication, 2,4-D dimethylamine, alkaline diuresis, chlorophenoxy

Abstract

Acute intoxication with 2,4-D dimethylamine is rare, often fatal and can cause signs and symptoms in different organ systems. This case report describes the effectiveness of alkaline diuresis as a life-saving treatment for chlorophenoxy intoxication, especially in healthcare facilities without access to haemodialysis. A patient had attempted suicide by ingesting 2,4-D dimethylamine, with toxic effects on the central and peripheral nervous systems, and the gastrointestinal and respiratory systems. However, she significantly improved after alkaline diuresis, accompanied by resuscitation, decontamination of the gastrointestinal system, and supportive therapies.

VIEW THE ENTIRE ARTICLE

References

  • Genetic Literacy Project. Herbicide-resistant crops can exacerbate ‘superweeds’ but new GM versions can help control problem. Available from: https://geneticliteracyproject.org/2014/06/27/herbicide-resistant-crops-can-exacerbate-superweeds-but-new-gm-versions-and-judicious-use-can-control-problem/ (accessed 15 Sep 2021).
  • Hiran S, Kumar S. 2, 4-D dichlorophenoxyacetic acid poisoning; case report and literature review. Asia Pacific J Med Toxicol 2017;6(1):29–33.
  • Bradberry SM, Watt BE, Proudfoot AT, Vale JA. Mechanisms of toxicity, clinical features, and management of acute chlorophenoxy herbicide poisoning: a review. J Toxicol Clin Toxicol 2000;38(2):111–22.
  • Bradberry SM, Proudfoot AT, Vale JA. Poisoning due to chlorophenoxy herbicides. Toxicol Rev 2004;23(2):65–73.

    • Views: 1960
    HTML downloads: 1229
    PDF downloads: 533

    Published: 2022-01-19
    Issue: 2022: Vol 9 No 1 (view)

    How to cite:
    1.
    Badu AB, Cempakadewi AA, Budihardja BM, Ake A. Alkaline Diuresis as Treatment for 2,4-D Dimethylamine Herbicide Intoxication. EJCRIM 2022;9 doi:10.12890/2022_003126.