Acquired Amegakaryocytic Thrombocytopenia Progressingto Aplastic Anaemia
  • Syed Ather Hussain
    Department of Internal Medicine, Rochester General Hospital, Rochester, NY, USA
  • Huda Fatima
    Department of Internal Medicine, Mercy Health St. Vincent Medical Center, Toledo, OH, USA
  • Hafsa Faisal
    Department of Internal Medicine, Rochester General Hospital, Rochester, NY, USA
  • Meenakshi Bansal
    Department of Pathology, Rochester General Hospital, Rochester, NY, USA


Acquired amegakaryocytic thrombocytopenia, aplastic anaemia, haematopoietic stem cell transplant


Acquired amegakaryocytic thrombocytopenia (AAMT) is a rare disorder of the bone marrow characterized by a lack of megakaryocytes and preservation of other cell lines. It can occur due to an intrinsic stem cell defect or secondary to viral infections, autoimmune disorders, lymphoproliferative disorders or environmental toxins. With time, it can progress to aplastic anaemia (AA) and can have a poor prognosis. No standard guidelines exist for the treatment of AAMT progressing to AA. Herein, we report a rare case of AAMT leading to AA and review the handful of cases previously published in the literature.



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    Published: 2022-09-05
    Issue: 2022: Vol 9 No 9 (view)

    How to cite:
    Hussain SA, Fatima H, Faisal H, Bansal M. Acquired Amegakaryocytic Thrombocytopenia Progressingto Aplastic Anaemia. EJCRIM 2022;9 doi:10.12890/2022_003479.