Acute Recurrent Pericarditis as the Inaugural Manifestation of Familial Mediterranean Fever

  • Attout Hassene Internal Medicine Unit, General Hospital Les Cevennes, Ales, France
  • Sofia Amichi Internal Medicine Unit, General Hospital Les Cevennes, Ales, France
  • Hichem Bouhamla Internal Medicine Unit, General Hospital Les Cevennes, Ales, France

Keywords

Pericarditis, familial Mediterranean fever

Abstract

Familial Mediterranean fever (FMF) is an inherited autosomal recessive disorder commonly found among individuals of Mediterranean or Middle Eastern descent and caused by Mediterranean Fever gene (MEFV) mutations on chromosome 16. It is the most frequent periodic febrile syndrome among the autoinflammatory syndromes. Typical febrile attacks include serosal inflammation, but although FMF is characterized by recurrent polyserositis, there is a little documentation of pericardial disease among patients. 

We report the case of a patient who presented recurrent pericarditis. Each episode occurred with a high fever and elevation of the C-reactive protein level. Treatment with colchicine was effective. The patient was found to be heterozygous for the V726A mutation. 

VIEW THE ENTIRE ARTICLE

References

  • Imazio M, Adler Y, Charron P. Recurrent pericarditis: modern approach in 2016. Curr Cardiol Rep 2016;18(6):50.
  • Sohar E, Gafni J, Pras M, Heller H. Familial Mediterranean fever. A survey of 470 cases. Am J Med 1967;43:227–253.
  • Kees S, Langevitz P, Zemer D, Padeh S, Pras M, Livneh A. Attacks of pericarditis as a manifestation of familial Mediterranean fever. QJM 1997;90(10):643–647.
  • Tunca M, Akar S, Onen F, Ozdogan H, Kasapcopur O, Yalcinkaya F, et al. Turkish FMF study group. Medicine (Baltimore) 2005;84(1):1–11.
  • Dabestani A, Noble JM, Child JS, Krivokapich J, Schawbe AD. Pericardial disease in familial Mediterranean fever: an echocardiographic study. Chest 1982;81:592–595.
  • Alsarah A, Alsara O, Laird-Fick HS. Cardiac manifestations of familial Mediterranean fever. Avicenna J Med 2017;7(4):158–163.
  • Ercan Tutar H, Imamoglu A, Atalay S. Recurrent pericarditis as a manifestation of familial Mediterranean fever. Circulation 2000;101(5):E71–E72.
  • Okutur K, Seber S, Oztekin E, Bes C, Borlu F. Recurrent pericarditis as the initial manifestation of familial Mediterranean fever. Med Sci Monit 2008;14:CS139–141.
  • Published: 2022-09-08

    Issue: 2022: LATEST ONLINE (view)

    Section: Articles

    How to cite:
    1.
    Hassene A, Amichi S, Bouhamla H. Acute Recurrent Pericarditis as the Inaugural Manifestation of Familial Mediterranean Fever . EJCRIM 2022;doi:10.12890/2022_003542.