Acute respiratory distress syndrome due to monkeypox virus
  • Tona Tchoubou
    Intensive Care Unit, Delafontaine Hospital, Saint-Denis, France
  • Rima El-Hosni
    Pulmonology and Infectious Diseases Department, Delafontaine Hospital, Saint-Denis, France
  • Marion Dollat
    Infectious Diseases Department, Delafontaine Hospital, Saint-Denis, France
  • Pierre Jaquet
    Intensive Care Unit, Delafontaine Hospital, Saint-Denis, France
  • Celine Tournus
    Microbiology Department, Delafontaine Hospital, Saint-Denis, France
  • Yacine Tandjaoui-Lambiotte
    Pulmonology and Infectious Diseases Department, Delafontaine Hospital, Saint-Denis, France; INSERM U1272 Hypoxia and the Lung, 93000; INSERM UMR 1137 IAME, Paris, France
  • Daniel Da Silva
    Intensive Care Unit, Delafontaine Hospital, Saint-Denis, France

Keywords

Monkeypox virus, ARDS, viraemia, tecovirimat, skin rash

Abstract

We report the first case of monkeypox virus (MPXV) associated acute respiratory distress syndrome (ARDS). A 34-year-old French woman with no medical history was admitted to the intensive care unit (ICU) for fever, altered mental status, hypotension and hypoxaemia. She presented with a diffuse skin rash with vesiculopustular lesions involving the four limbs and perineal ulcers with a skin swab positive for MPXV. On day 2, the patient presented moderate ARDS requiring invasive mechanical ventilation. She also had pleural empyema due to Streptococcus pyogenes. MPXV PCR was positive in the bronchoalveolar lavage, the pleural effusion and the blood. The patient was treated with tecovirimat. Despite the treatment, she had persistent viraemia for at least ten days. The patient condition rapidly improved; she was weaned from mechanical ventilation on day 18 despite the persistence of radiological lung opacities. She fully recovered and was discharged home on day 38 after admission.

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    Published: 2023-10-19
    Issue: 2023: Vol 10 No 11 (view)


    How to cite:
    1.
    Tchoubou T, El-Hosni R, Dollat M, Jaquet P, Tournus C, Tandjaoui-Lambiotte Y, Da Silva D. Acute respiratory distress syndrome due to monkeypox virus. EJCRIM 2023;10 doi:10.12890/2023_004126.