Azathioprine associated with intrahepatic cholestasis in a patient with twin pregnancy after a second kidney transplant
  • Lamis Khedr
    Nephrology Department, Ain Shams University, Cairo, Egypt
  • Mohamed Ekram
    Internal Medicine Department, New Giza University, Cairo, Egypt


Kidney transplant, azathioprine, pregnancy, intrahepatic cholestasis


Introduction: Most pregnancies in women after a kidney transplant result in a live birth, but kidney functions should be stable for one year before conception. For immunosuppression modification occurring before pregnancy, azathioprine is used because it is considered safe for major congenital malformations during pregnancy. However, there may be an association between exposure to azathioprine during pregnancy and the onset of an unusual, early and severe form of intrahepatic cholestasis.
Case description: A young patient with a twin pregnancy after a second kidney transplant experienced intrahepatic cholestasis. There was a wide range of differential diagnosis. A battery of tests was requested including autoimmune markers, virology, and imaging. The conclusion that azathioprine was contributing to intrahepatic cholestasis with pregnancy was reached after exclusion of all other differentials.
Conclusions: Complications of pregnancy after a kidney transplant include hypertension, pre-eclampsia, deterioration of graft function up to rejection, but also unusual side effects of immunosuppression medication.



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    Published: 2024-03-11
    Issue: 2024: Vol 11 No 4 (view)

    How to cite:
    Khedr L, Ekram M. Azathioprine associated with intrahepatic cholestasis in a patient with twin pregnancy after a second kidney transplant. EJCRIM 2024;11 doi:10.12890/2024_004385.