A silent cause of shock: autoimmune polyglandular syndromes
  • Mark Colantonio
    Department of Medicine, West Virginia University, Morgantown, USA
  • Michelle Hartzell
    Department of Medicine, West Virginia University, Morgantown, USA
  • Brooke Shannon
    Department of Medicine, West Virginia University, Morgantown, USA
  • Apoorva Iyer
    Department of Medicine, Division of Endocrinology, Morgantown, USA


Adrenal insufficiency, Addison’s disease, Hashimoto’s disease, autoimmune polyglandular syndromes, autoimmune polyendocrine syndrome type 2


Addison’s disease is a rare, autoimmune condition leading to the destruction of the adrenal gland. Autoimmune conditions are known to commonly co-occur. When Addison’s disease presents in the setting of autoimmune thyroid disease and/or type 1 diabetes, this condition is termed autoimmune polyendocrine syndrome type II, a rare endocrinopathy found in roughly 1.4-4.5 per 100,000 individuals. Here, we describe a clinical case presenting with hypotension refractory to fluid resuscitation and electrolyte derangements later diagnosed as autoimmune polyendocrine syndrome type II.



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    Published: 2024-05-27
    Issue: 2024: Vol 11 No 6 (view)

    How to cite:
    Colantonio M, Hartzell M, Shannon B, Iyer A. A silent cause of shock: autoimmune polyglandular syndromes. EJCRIM 2024;11 doi:10.12890/2024_004627.